Nallanthighal Sameera, Heiserman James Patrick, Cheon Dong-Joo
Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USA.
Cancers (Basel). 2021 Feb 24;13(5):935. doi: 10.3390/cancers13050935.
Collagen type XI alpha 1 (COL11A1), one of the three alpha chains of type XI collagen, is crucial for bone development and collagen fiber assembly. Interestingly, COL11A1 expression is increased in several cancers and high levels of COL11A1 are often associated with poor survival, chemoresistance, and recurrence. This review will discuss the recent discoveries in the biological functions of COL11A1 in cancer. COL11A1 is predominantly expressed and secreted by a subset of cancer-associated fibroblasts, modulating tumor-stroma interaction and mechanical properties of extracellular matrix. COL11A1 also promotes cancer cell migration, metastasis, and therapy resistance by activating pro-survival pathways and modulating tumor metabolic phenotype. Several inhibitors that are currently being tested in clinical trials for cancer or used in clinic for other diseases, can be potentially used to target COL11A1 signaling. Collectively, this review underscores the role of COL11A1 as a promising biomarker and a key player in cancer.
XI型胶原蛋白α1链（COL11A1）是XI型胶原蛋白的三条α链之一，对骨骼发育和胶原纤维组装至关重要。有趣的是，COL11A1在几种癌症中的表达增加，高水平的COL11A1通常与生存率低、化疗耐药性和复发相关。本综述将讨论COL11A1在癌症生物学功能方面的最新发现。COL11A1主要由一部分癌症相关成纤维细胞表达和分泌，调节肿瘤-基质相互作用和细胞外基质的力学性质。COL11A1还通过激活促生存途径和调节肿瘤代谢表型来促进癌细胞迁移、转移和治疗耐药性。目前正在癌症临床试验中测试或用于其他疾病临床治疗的几种抑制剂，可能可用于靶向COL11A1信号传导。总的来说，本综述强调了COL11A1作为一种有前景的生物标志物和癌症关键参与者的作用。
