Chung Seung Ah, Lee Hae Sang, Kim Seung Woo, Hwang Jin Soon
Department of Ophthalmology, Ajou University School of Medicine, Suwon 16499, Korea.
Department of Pediatrics, Ajou University School of Medicine, Suwon 16499, Korea.
Children (Basel). 2021 Feb 24;8(3):171. doi: 10.3390/children8030171.
We sought to determine whether the myopic progression of patients with central precocious puberty (CPP) who were undergoing treatment differed from that of their healthy peers with normal pubertal onset and progression. Eighteen girls with CPP and 14 age-matched controls who underwent regular ophthalmic examinations for at least 1 year were included. All the CPP patients received a 3.75 mg leuprolide acetate depot subcutaneously every 28 days. The spherical equivalent (SE) and axial length (AL) for myopia progression and the pubertal parameters (height, body weight, body mass index, Tanner stage, and bone age) were compared between the two groups. Of 32 subjects with a mean age of 8.6 ± 0.7 years, the SEs and ALs did not differ at baseline between the two groups, which had similar weight and similar body mass index. After 1 year, both the CPP patients and controls showed myopic progression, with an average myopic shift of -0.73 ± 0.48 diopters (D) and AL elongation with a mean change of 0.44 ± 0.61 mm. The SE and AL changes over 1 year were greater in the controls than those in the CPP patients, which was not statistically significant (-0.85 ± 0.55 D vs. -0.64 ± 0.41 D and 0.55 ± 0.89 mm vs. 0.35 ± 0.22 mm, respectively). The change in AL correlated significantly with the change in the height ( = 0.691, = 0.039). In this 1-year study, the CPP patients with treatments trended to show less myopic progression than the controls.
我们试图确定正在接受治疗的中枢性性早熟（CPP）患者的近视进展情况是否与其青春期正常启动和进展的健康同龄人不同。纳入了18名患有CPP的女孩和14名年龄匹配的对照者，这些对照者接受了至少1年的定期眼科检查。所有CPP患者每28天皮下注射一次3.75mg醋酸亮丙瑞林长效制剂。比较了两组之间近视进展的等效球镜（SE）和眼轴长度（AL）以及青春期参数（身高、体重、体重指数、 Tanner分期和骨龄）。在32名平均年龄为8.6±0.7岁的受试者中，两组的SE和AL在基线时无差异，体重和体重指数相似。1年后，CPP患者和对照者均出现近视进展，平均近视偏移为-0.73±0.48屈光度（D），眼轴伸长，平均变化为0.44±0.61mm。对照组1年内的SE和AL变化大于CPP患者，但差异无统计学意义（分别为-0.85±0.55D对-0.64±0.41D和0.55±0.89mm对0.35±0.22mm）。眼轴长度的变化与身高变化显著相关（r = 0.691，P = 0.039）。在这项为期1年的研究中，接受治疗的CPP患者的近视进展趋势低于对照组。
