Lee Jason W, Somerville Tobi, Kaye Stephen B, Romano Vito
School of Medicine, University of Liverpool, Liverpool L69 3GE, UK.
Department of Eye and Vision Science, University of Liverpool, Liverpool L7 8TX, UK.
J Clin Med. 2021 Feb 13;10(4):758. doi: 10.3390/jcm10040758.
Bacterial keratitis is a devastating condition that can rapidly progress to serious complications if not treated promptly. Certain causative microorganisms such as and are notorious for their resistance to antibiotics. Resistant bacterial keratitis results in poorer outcomes such as scarring and the need for surgical intervention. Thorough understanding of the causative pathogen and its virulence factors is vital for the discovery of novel treatments to avoid further antibiotic resistance. While much has been previously reported on , has been less extensively studied. This review aims to give a brief overview of epidemiology, pathophysiology and clinical characteristics as well as summarise the current evidence for potential novel therapies.
细菌性角膜炎是一种严重的疾病，如果不及时治疗，会迅速发展为严重的并发症。某些致病微生物，如……和……，因其对抗生素的耐药性而臭名昭著。耐药性细菌性角膜炎会导致更差的预后，如瘢痕形成以及需要手术干预。全面了解致病病原体及其毒力因子对于发现新的治疗方法以避免进一步的抗生素耐药性至关重要。虽然之前已经有很多关于……的报道，但……的研究较少。本综述旨在简要概述……的流行病学、病理生理学和临床特征，并总结当前潜在新疗法的证据。
