Argonaute蛋白在癌症中占据核心地位。

Nowak Iwona, Sarshad Aishe A

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.

Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, 405 30 Gothenburg, Sweden.

Cancers (Basel). 2021 Feb 13;13(4):788. doi: 10.3390/cancers13040788.

Argonaute proteins (AGOs) play crucial roles in RNA-induced silencing complex (RISC) formation and activity. AGOs loaded with small RNA molecules (miRNA or siRNA) either catalyze endoribonucleolytic cleavage of target RNAs or recruit factors responsible for translational silencing and target destabilization. miRNAs are well characterized and broadly studied in tumorigenesis; nevertheless, the functions of the AGOs in cancers have lagged behind. Here, we discuss the current state of knowledge on the role of AGOs in tumorigenesis, highlighting canonical and non-canonical functions of AGOs in cancer cells, as well as the biomarker potential of AGO expression in different of tumor types. Furthermore, we point to the possible application of the AGOs in development of novel therapeutic approaches.

Argonaute蛋白（AGO）在RNA诱导沉默复合体（RISC）的形成和活性中发挥关键作用。装载有小RNA分子（miRNA或siRNA）的AGO要么催化靶RNA的核糖核酸内切酶切割，要么招募负责翻译沉默和靶标去稳定化的因子。miRNA在肿瘤发生过程中已得到充分表征并被广泛研究；然而，AGO在癌症中的功能研究却滞后了。在此，我们讨论目前关于AGO在肿瘤发生中作用的知识现状，重点介绍AGO在癌细胞中的经典和非经典功能，以及AGO表达在不同肿瘤类型中的生物标志物潜力。此外，我们指出AGO在新型治疗方法开发中的可能应用。