Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Department for Microgravity Research and Translational Regenerative Medicine, Otto-von-Guericke University, D-39106 Magdeburg, Germany.
Int J Mol Sci. 2021 Feb 25;22(5):2300. doi: 10.3390/ijms22052300.
Obstructive sleep apnea (OSA) is a common disease, with approximately 3-7% of men and 2-5% of women worldwide suffering from symptomatic OSA. If OSA is left untreated, hypoxia, microarousals and increased chemoreceptor stimulation can lead to complications like hypertension (HT). Continuous positive airway pressure (CPAP) is the most common treatment for OSA, and it works by generating airway patency, which will counteract the apnea or hypopnea. More than one billion people in the world suffer from HT, and the usual treatment is pharmacological with antihypertensive medication (AHM). The focus of this review will be to investigate whether the CPAP therapy for OSA affects HT.
阻塞性睡眠呼吸暂停(OSA)是一种常见疾病,全球约有 3-7%的男性和 2-5%的女性患有症状性 OSA。如果 OSA 得不到治疗,缺氧、微觉醒和化学感受器刺激增加可导致高血压(HT)等并发症。持续气道正压通气(CPAP)是治疗 OSA 最常用的方法,它通过产生气道通畅来对抗呼吸暂停或呼吸不足。全世界有超过 10 亿人患有 HT,通常的治疗方法是使用降压药物(AHM)进行药物治疗。本综述的重点将是研究 OSA 的 CPAP 治疗是否会影响 HT。