Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia.
School of Pharmacy and Pharmacology, Griffith University, Gold Coast, QLD 4222, Australia.
Biomolecules. 2021 Feb 25;11(3):353. doi: 10.3390/biom11030353.
Depression is a psychiatric disorder that has a significant health burden on patients and their families. Unfortunately, the current antidepressant medications that mainly target monoamine neurotransmitters have limited efficacy. Recent evidence has indicated that neuroinflammation participates in the genesis and development of depression, and interacts with other factors involved in depression. Therefore, exploring effective anti-inflammatory medications could be beneficial for the development of new treatment options for depression. Sirtuins are a unique class of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, which have seven members that can affect multiple downstream targets by deacetylation activity. Among these seven members, SIRT1 and SIRT2 have been shown to participate in the pathophysiology of inflammation in numerous studies. Thus, in this short article, we review the association of SIRT1 and SIRT2 activity and depression, and evidence of the effects of SIRT1 and SIRT2 modulators on inflammation in vitro and depressive-like behaviours in vivo.
抑郁症是一种精神障碍，给患者及其家庭带来了重大的健康负担。不幸的是，目前主要针对单胺神经递质的抗抑郁药物疗效有限。最近的证据表明，神经炎症参与了抑郁症的发生和发展，并与抑郁症相关的其他因素相互作用。因此，探索有效的抗炎药物可能有助于开发新的抑郁症治疗选择。沉默调节蛋白是一类独特的烟酰胺腺嘌呤二核苷酸 (NAD) 依赖性去乙酰化酶，有 7 个成员，通过去乙酰化活性可以影响多个下游靶标。在这 7 个成员中，SIRT1 和 SIRT2 已被证明参与了众多研究中的炎症病理生理学。因此，在这篇短文中，我们回顾了 SIRT1 和 SIRT2 活性与抑郁症的关联，以及 SIRT1 和 SIRT2 调节剂对体外炎症和体内抑郁样行为的影响的证据。
