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低频经颅磁刺激改善慢性不可预测轻度应激小鼠的快感缺失行为并调节肠道微生物群。

Low-frequency Transcranial Magnetic Stimulation Ameliorates Anhedonic Behaviors and Regulates the Gut Microbiome in Mice Exposed to Chronic Unpredictable Mild Stress.

作者信息

Gao Linyin, Zhao Xiangwei, Wu Lei, Liu Chuan, Ding Ran, Wang Haitao, Shang Xueliang

机构信息

Hebei Key Laboratory for Chronic Diseases, Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, North China University of Science and Technology School of Basic Medical Sciences, Tang'shan, Hebei Province, P.R. China.

Department of Psychiatry, North China University of Science and Technology School of Psychology and Mental Health, Tang'shan, Hebei Province, P.R. China.

出版信息

Alpha Psychiatry. 2024 Aug 1;25(4):493-501. doi: 10.5152/alphapsychiatry.2024.241561. eCollection 2024 Aug.

DOI:10.5152/alphapsychiatry.2024.241561
PMID:39360304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11443298/
Abstract

OBJECTIVE

This paper presents a preliminary study on whether low-frequency transcranial magnetic stimulation (LF-TMS) can modulate the gut microbiota in mice with chronic unpredictable mild stress (CUMS).

METHODS

Mice received LF-TMS (1 Hz, 20 mT) for 28 consecutive days under chronic unpredictable mild stress (CUMS). The composition of gut microbiota of stool samples were tested.

RESULTS

CUMS caused significant changes in gut microbiotas, specifically in community diversity of gut microbiotas ( < .05). Compared with the stressed group mice, the Chao1 index ( < .05), Observed species index ( < .05), Faith's PD index ( < .05) and Shannon index ( < .05) of the LF-TMS treatment group were significantly increased. Furthermore, 1 Hz LF-TMS-treatment partially recovered chronic stress induced changes of microbiotas, such as the abundance of , .

CONCLUSION

These results manifested that LF-TMS treatment can improve the anhedonic behaviors caused by CUMS in mice, which are connected with regulating the related intestinal microbial community disturbance, including species diversity, structure of gut microbiota, and species composition.

摘要

目的

本文旨在对低频经颅磁刺激（LF-TMS）是否能调节慢性不可预测轻度应激（CUMS）小鼠的肠道微生物群进行初步研究。

方法

小鼠在慢性不可预测轻度应激（CUMS）条件下连续28天接受LF-TMS（1赫兹，20毫特斯拉）刺激。检测粪便样本中肠道微生物群的组成。

结果

CUMS导致肠道微生物群发生显著变化，特别是肠道微生物群的群落多样性（P<0.05）。与应激组小鼠相比，LF-TMS治疗组的Chao1指数（P<0.05）、观测物种指数（P<0.05）、Faith's PD指数（P<0.05）和香农指数（P<0.05）均显著升高。此外，1赫兹LF-TMS治疗部分恢复了慢性应激诱导的微生物群变化，如[具体微生物名称1]、[具体微生物名称2]的丰度。

结论

这些结果表明，LF-TMS治疗可改善CUMS诱导的小鼠快感缺失行为，这与调节相关肠道微生物群落紊乱有关，包括物种多样性、肠道微生物群结构和物种组成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/55f4d2309a79/ap-25-4-493_f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/5c920de330d4/ap-25-4-493_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/ebe3f117a25c/ap-25-4-493_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/f859390a79ba/ap-25-4-493_f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/7ebe375c2a62/ap-25-4-493_f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/55f4d2309a79/ap-25-4-493_f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/5c920de330d4/ap-25-4-493_f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/ebe3f117a25c/ap-25-4-493_f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/f859390a79ba/ap-25-4-493_f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/7ebe375c2a62/ap-25-4-493_f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a7c4/11443298/55f4d2309a79/ap-25-4-493_f005.jpg

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J Ethnopharmacol. 2023 Nov 15;316:116716. doi: 10.1016/j.jep.2023.116716. Epub 2023 Jun 8.
2
rTMS ameliorates depressive-like behaviors and regulates the gut microbiome and medium- and long-chain fatty acids in mice exposed to chronic unpredictable mild stress.rTMS 可改善慢性不可预测轻度应激小鼠的抑郁样行为，并调节其肠道微生物组和中长链脂肪酸。
CNS Neurosci Ther. 2023 Nov;29(11):3549-3566. doi: 10.1111/cns.14287. Epub 2023 Jun 2.
3
Neuroinflammation, Microbiota-Gut-Brain Axis, and Depression: The Vicious Circle.
神经炎症、微生物群-肠-脑轴与抑郁症：恶性循环。
J Integr Neurosci. 2023 May 8;22(3):65. doi: 10.31083/j.jin2203065.
4
Gut microbiota and its metabolites in depression: from pathogenesis to treatment.肠道微生物群及其代谢物与抑郁症：从发病机制到治疗。
EBioMedicine. 2023 Apr;90:104527. doi: 10.1016/j.ebiom.2023.104527. Epub 2023 Mar 22.
5
Low-frequency transcranial magnetic stimulation protects cognition in mice with chronic unpredictable mild stress through autophagy regulation.低频经颅磁刺激通过自噬调节保护慢性不可预测轻度应激小鼠的认知功能。
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6
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J Neuroinflammation. 2023 Feb 3;20(1):23. doi: 10.1186/s12974-023-02693-1.
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Antidepressant Active Components of Bupleurum chinense DC-Paeonia lactiflora Pall Herb Pair: Pharmacological Mechanisms.柴胡-白芍药对的抗抑郁活性成分：药理学机制。
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Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression.抑郁症中的小胶质细胞：抑郁症发病机制和治疗中小胶质细胞的概述。
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