Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Walloon Excellence in Life Sciences and BIOtechnology (WELBIO), UCLouvain, Université Catholique de Louvain, Av. E. Mounier, 73 B1.73.11, 1200 Brussels, Belgium.
Cells. 2021 Feb 16;10(2):400. doi: 10.3390/cells10020400.
Among the myriad of molecules produced by the liver, both bile acids and their precursors, the oxysterols are becoming pivotal bioactive lipids which have been underestimated for a long time. Their actions are ranging from regulation of energy homeostasis (i.e., glucose and lipid metabolism) to inflammation and immunity, thereby opening the avenue to new treatments to tackle metabolic disorders associated with obesity (e.g., type 2 diabetes and hepatic steatosis) and inflammatory diseases. Here, we review the biosynthesis of these endocrine factors including their interconnection with the gut microbiota and their impact on host homeostasis as well as their attractive potential for the development of therapeutic strategies for metabolic disorders.
在肝脏产生的众多分子中，胆汁酸及其前体——氧化固醇正在成为重要的生物活性脂质，它们长期以来一直被低估。它们的作用范围从调节能量稳态（即葡萄糖和脂质代谢）到炎症和免疫，从而为治疗与肥胖相关的代谢紊乱（如 2 型糖尿病和肝脂肪变性）和炎症性疾病开辟了新的治疗途径。在这里，我们综述了这些内分泌因子的生物合成，包括它们与肠道微生物群的相互联系及其对宿主稳态的影响，以及它们在开发代谢紊乱治疗策略方面的诱人潜力。
