酒精性肝病的历史：从一种未被认识的疾病到肝病学中最常见的疾病之一。
The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology.
作者信息
Seitz Helmut K, Neuman Manuela G
机构信息
Centre of Liver and Alcohol Diseases, Ethianum Clinic, 69115 Heidelberg, Germany.
Faculty of Medicine, University of Heidelberg, 69117 Heidelberg, Germany.
出版信息
J Clin Med. 2021 Feb 19;10(4):858. doi: 10.3390/jcm10040858.
Abstract
This review describes the history of alcoholic liver disease from the beginning of the 1950s until now. It details how the hepatotoxicity of alcohol was discovered by epidemiology and basic research primarily by using new feeding techniques in rodents and primates. The article also recognizes the pioneering work of scientists who contributed to the understanding of the pathophysiology of alcoholic liver disease. In addition, clinical aspects, such as the development of diagnostics and treatment options for alcoholic liver disease, are discussed. Up-to-date knowledge of the mechanism of the disease in 2020 is presented.
摘要
本综述描述了从20世纪50年代初至今酒精性肝病的历史。它详细介绍了酒精的肝毒性是如何通过流行病学以及主要利用啮齿动物和灵长类动物的新喂养技术进行的基础研究发现的。文章还认可了为理解酒精性肝病病理生理学做出贡献的科学家的开创性工作。此外，还讨论了临床方面的内容，如酒精性肝病诊断和治疗方案的发展。文中呈现了2020年该疾病机制的最新知识。
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