精神分裂症中的催产素：病理生理学及对未来治疗的启示。
Oxytocin in Schizophrenia: Pathophysiology and Implications for Future Treatment.
机构信息
Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
Psychiatric Research Center, Wan-Fang Hospital, Taipei Medical University, Taipei 116, Taiwan.
出版信息
Int J Mol Sci. 2021 Feb 21;22(4):2146. doi: 10.3390/ijms22042146.
Abstract
Schizophrenia is a form of mental disorder that is behaviorally characterized by abnormal behavior, such as social function deficits or other behaviors that are disconnected from reality. Dysregulation of oxytocin may play a role in regulating the expression of schizophrenia. Given oxytocin's role in social cognition and behavior, a variety of studies have examined the potential clinical benefits of oxytocin in improving the psychopathology of patients with schizophrenia. In this review, we highlight the evidence for the role of endogenous oxytocin in schizophrenia, from animal models to human studies. We further discuss the potential of oxytocin as a therapeutic agent for schizophrenia and its implication in future treatment.
摘要
精神分裂症是一种行为特征为异常行为的精神障碍，例如社交功能缺陷或与现实脱节的其他行为。催产素的失调可能在调节精神分裂症的表达中发挥作用。鉴于催产素在社会认知和行为中的作用，许多研究都检查了催产素在改善精神分裂症患者精神病理学方面的潜在临床益处。在这篇综述中，我们从动物模型到人类研究，强调了内源性催产素在精神分裂症中的作用证据。我们还进一步讨论了催产素作为精神分裂症治疗剂的潜力及其对未来治疗的影响。
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