Skouropoulou Despoina, Lacitignola Luca, Di Bella Caterina, Stabile Marzia, Acquafredda Claudia, Brienza Nicola, Grasso Salvatore, Crovace Antonio, Iarussi Fabrizio, Staffieri Francesco
Section of Veterinary Clinics and Animal Production, Department of Emergency and Organ Transplantation, Aldo Moro University, 70010 Bari, Italy.
Ph.D. Course in Organs and Tissues Transplantation and Cellular Therapies, Department of Emergency and Organ Transplantations, Aldo Moro University, 70124 Bari, Italy.
Vet Sci. 2021 Feb 11;8(2):26. doi: 10.3390/vetsci8020026.
The aim of this study was to evaluate the incidence of fluid responsiveness (FR) to a fluid challenge (FC) in normotensive dogs under anaesthesia. The accuracy of pulse pressure variation (PPV), systolic pressure variation (SPV), stroke volume variation (SVV), and plethysmographic variability index (PVI) for predicting FR was also evaluated. Dogs were anaesthetised with methadone, propofol, and inhaled isoflurane in oxygen, under volume-controlled mechanical ventilation. FC was performed by the administration of 5 mL/kg of Ringer's lactate within 5 min. Cardiac index (CI; L/min/m), PPV, (%), SVV (%), SPV (%), and PVI (%) were registered before and after FC. Data were analysed with ANOVA and ROC tests ( < 0.05). Fluid responsiveness was defined as 15% increase in CI. Eighty dogs completed the study. Fifty (62.5%) were responders and 30 (37.5%) were nonresponders. The PPV, PVI, SPV, and SVV cut-off values (AUC, ) for discriminating responders from nonresponders were PPV >13.8% (0.979, <0.001), PVI >14% (0.956, <0.001), SPV >4.1% (0.793, <0.001), and SVV >14.7% (0.729, <0.001), respectively. Up to 62.5% of normotensive dogs under inhalant anaesthesia may be fluid responders. PPV and PVI have better diagnostic accuracy to predict FR, compared to SPV and SVV.
本研究的目的是评估麻醉状态下血压正常的犬对液体冲击（FC）的液体反应性（FR）发生率。同时还评估了脉压变异（PPV）、收缩压变异（SPV）、每搏量变异（SVV）和容积描记变异性指数（PVI）预测FR的准确性。犬在容量控制机械通气下，用美沙酮、丙泊酚和氧气吸入异氟醚麻醉。通过在5分钟内给予5 mL/kg乳酸林格氏液进行FC。在FC前后记录心脏指数（CI；L/min/m）、PPV（%）、SVV（%）、SPV（%）和PVI（%）。数据采用方差分析和ROC检验进行分析（<0.05）。液体反应性定义为CI增加15%。80只犬完成了研究。50只（62.5%）为反应者，30只（37.5%）为无反应者。区分反应者和无反应者的PPV、PVI、SPV和SVV临界值（AUC，）分别为PPV>13.8%（0.979，<0.001）、PVI>14%（0.956，<0.001）、SPV>4.1%（0.793，<0.001）和SVV>14.7%（0.729，<0.001）。吸入麻醉下高达62.5%的血压正常犬可能是液体反应者。与SPV和SVV相比，PPV和PVI对预测FR具有更好的诊断准确性。
