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Complex属（炭角菌科，炭角菌目）的分类解析及其两种重要次生代谢产物的发现与生物学特性研究

Resolution of the Complex (Hypoxylaceae, Xylariales) and Discovery and Biological Characterization of Two of Its Prominent Secondary Metabolites.

作者信息

Lambert Christopher, Pourmoghaddam Mohammad Javad, Cedeño-Sanchez Marjorie, Surup Frank, Khodaparast Seyed Akbar, Krisai-Greilhuber Irmgard, Voglmayr Hermann, Stradal Theresia E B, Stadler Marc

机构信息

Helmholtz-Centre for Infection Research GmbH, Department of Microbial Drugs, Inhoffenstraße 7, 38124 Braunschweig, Germany.

German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany.

出版信息

J Fungi (Basel). 2021 Feb 11;7(2):131. doi: 10.3390/jof7020131.

DOI:10.3390/jof7020131
PMID:33670169
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7916920/
Abstract

a large, cosmopolitan genus of Ascomycota is in the focus of our current poly-thetic taxonomic studies, and served as an excellent source for bioactive secondary metabolites at the same time. The present work concerns a survey of the species complex based on specimens from Iran and Europe by morphological studies and high performance liquid chromatography coupled to mass spectrometry and diode array detection (HPLC-MS-DAD). Apart from known chemotaxonomic markers like binaphthalene tetrol (BNT) and daldinin F, two unprece-dented molecules were detected and subsequently isolated to purity by semi preparative HPLC. Their structures were established by nuclear-magnetic resonance (NMR) spectroscopy as 3'-malonyl-daldinin F () and pseudofuscochalasin A (). The new daldinin derivative showed weak cytotoxicity towards mammalian cells but bactericidal activity. The new cytochalasin was compared to cytochalasin C in an actin disruption assay using fluorescence microscopy of human osteo-sarcoma U2OS cells, revealing comparable activity towards F-actin but being irreversible compared to cytochalasin C. Concurrently, a multilocus molecular phylogeny based on ribosomal and proteinogenic nucleotide sequences of species resulted in a well-supported clade for and its allies. From a comparison of morphological, chemotaxonomic and phylogenetic evidence, we introduce the new species and .

摘要

一个大型的、世界性的子囊菌属是我们当前多性状分类研究的重点，同时也是生物活性次级代谢产物的一个极好来源。本研究工作通过形态学研究以及高效液相色谱-质谱联用和二极管阵列检测（HPLC-MS-DAD），对来自伊朗和欧洲的标本所构成的物种复合体进行了调查。除了已知的化学分类学标记如联萘四醇（BNT）和达尔迪宁F之外，还检测到了两个前所未有的分子，并随后通过半制备HPLC将其分离至纯品。通过核磁共振（NMR）光谱确定了它们的结构，分别为3'-丙二酰-达尔迪宁F（）和假暗褐孢菌素A（）。新的达尔迪宁衍生物对哺乳动物细胞显示出较弱的细胞毒性，但具有杀菌活性。在使用人骨肉瘤U2OS细胞的荧光显微镜进行的肌动蛋白破坏试验中，将新的细胞松弛素与细胞松弛素C进行了比较，结果表明其对F-肌动蛋白的活性相当，但与细胞松弛素C相比具有不可逆性。同时，基于该属物种的核糖体和蛋白质编码核苷酸序列构建的多位点分子系统发育树，为该属及其近缘种形成了一个得到充分支持的分支。通过对形态学、化学分类学和系统发育学证据的比较，我们描述了新物种和。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/60f8d3dc8210/jof-07-00131-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/624e704e5b16/jof-07-00131-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/a68fffcdb8ee/jof-07-00131-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/967ce263a4ff/jof-07-00131-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/84684eb470ba/jof-07-00131-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/ca7f431d2223/jof-07-00131-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/8dd193a1d282/jof-07-00131-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/60f8d3dc8210/jof-07-00131-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/624e704e5b16/jof-07-00131-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/a68fffcdb8ee/jof-07-00131-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/967ce263a4ff/jof-07-00131-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/84684eb470ba/jof-07-00131-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/ca7f431d2223/jof-07-00131-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/8dd193a1d282/jof-07-00131-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/634c/7916920/60f8d3dc8210/jof-07-00131-g007.jpg

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