Grewal Simran, Oosterling Steven J, van Egmond Marjolein
Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Centers, 1007 MB Amsterdam, The Netherlands.
Department of Surgery, Amsterdam University Medical Centers, 1081 HV Amsterdam, The Netherlands.
Biomedicines. 2021 Feb 11;9(2):177. doi: 10.3390/biomedicines9020177.
Surgery is a crucial intervention and provides the best chance of cure for patients with colorectal cancer. Experimental and clinical evidence, however, suggests that paradoxically surgery itself may precipitate or accelerate tumor recurrence and/or liver metastasis development. This review addresses the various aspects of surgery-induced metastasis formation and sheds light on the role of inflammation as potential trigger for metastasis development. Understanding these mechanisms may provide potential new perioperative interventions to improve treatment outcomes, and as such could transform the perioperative timeframe from a facilitator of metastatic progression to a window of opportunity to reduce the risk of liver metastasis development. Ultimately, this can potentially improve long-term survival rates and quality of life in patients with colorectal cancer.
手术是一种关键的干预措施，为结直肠癌患者提供了最佳的治愈机会。然而，实验和临床证据表明，自相矛盾的是，手术本身可能会促使或加速肿瘤复发和/或肝转移的发展。本综述探讨了手术诱导转移形成的各个方面，并阐明了炎症作为转移发展潜在触发因素的作用。了解这些机制可能会提供潜在的新的围手术期干预措施，以改善治疗效果，从而有可能将围手术期从转移进展的促进阶段转变为降低肝转移发生风险的机会窗口。最终，这有可能提高结直肠癌患者的长期生存率和生活质量。
