Dancer S J, Simmons N A, Poston S M, Noble W C
Department of Clinical Bacteriology and Virology, Guy's Hospital, London, U.K.
J Infect. 1988 Jan;16(1):87-103. doi: 10.1016/s0163-4453(88)96249-4.
Over a period of 2 months, 12 babies born in the maternity unit at Guy's Hospital developed staphylococcal scalded skin syndrome in two distinct outbreaks. Staphylococci isolated from the babies, together with those from the mothers and attending medical staff were phage-typed. All isolates from the babies were of type 3A/3C. During the first outbreak only one carrier of the epidemic strain (a paediatrician) was found but a further 12 persons were identified as possible carriers during the second outbreak. In order to confirm the link between outbreaks, all phage group II isolates were subjected to reverse phage-typing, testing for metal-ion resistance, plasmid profiling and in-vivo testing for production of epidermolytic toxin. It was shown that the same epidemic strain of toxin-producing Staphylococcus aureus was responsible for both outbreaks. The affected neonates responded rapidly to a short course of intravenous flucloxacillin. The outbreak ceased after appropriate treatment of all carriers and the implementation of an extensive disinfection policy within the maternity unit.
在两个月的时间里，盖伊医院产科病房出生的12名婴儿分两次爆发了葡萄球菌烫伤样皮肤综合征。对从婴儿、母亲及医护人员身上分离出的葡萄球菌进行了噬菌体分型。从婴儿身上分离出的所有菌株均为3A/3C型。在首次爆发期间，仅发现一名流行菌株携带者（一名儿科医生），但在第二次爆发期间又确定了另外12人可能为携带者。为了证实两次爆发之间的关联，对所有噬菌体II组分离株进行了反向噬菌体分型、金属离子抗性测试、质粒图谱分析以及表皮溶解毒素产生的体内测试。结果表明，两次爆发均由同一株产毒素的金黄色葡萄球菌流行菌株引起。受影响的新生儿对短期静脉注射氟氯西林治疗反应迅速。在对所有携带者进行适当治疗并在产科病房实施广泛的消毒政策后，疫情得以平息。
