Ladhani S, Bhutta Z A
Department of Paediatrics, The Agakhan University Hospital, Karachi, Pakistan.
Eur J Clin Microbiol Infect Dis. 1998 Sep;17(9):642-4. doi: 10.1007/BF01708347.
A case of neonatal Pseudomonas putida sepsis presenting as staphylococcal scalded skin syndrome is described. Staphylococcal scalded skin syndrome is a clinical term used for a spectrum of primarily neonatal blistering skin disorders caused by the exfoliative toxins of Staphylococcus aureus. The disease typically begins with general erythema and fever, followed by the formation of large fluid-filled bullae that coalesce and rupture on slightest pressure to leave extensive areas of denuded skin. The 9-day-old male infant described presented with a generalised non-tender, macular, erythematous rash that later developed into large, flaccid, clear fluid-filled bullae to leave extensive erythematous, weeping, and denuded areas covering over 90% of the total body surface. Despite aggressive antibiotic and symptomatic treatment, he died 11 days after admission. While Pseudomonas infections may present with vesico-bullous eruptions, this is believed to be the first case of neonatal Pseudomonas putida sepsis presenting as staphylococcal scalded skin syndrome.
本文描述了一例表现为葡萄球菌烫伤样皮肤综合征的新生儿恶臭假单胞菌败血症病例。葡萄球菌烫伤样皮肤综合征是一个临床术语，用于描述一系列主要由金黄色葡萄球菌剥脱毒素引起的新生儿水疱性皮肤疾病。该病通常始于全身红斑和发热，随后形成大的充满液体的水疱，水疱融合，稍有压力就会破裂，留下大面积皮肤剥脱区域。所述9日龄男婴最初表现为全身性无痛性斑疹、红斑疹，随后发展为大的、松弛的、充满清亮液体的水疱，留下大面积红斑、渗液及皮肤剥脱区域，覆盖全身表面积的90%以上。尽管给予了积极的抗生素治疗和对症治疗，但患儿入院11天后死亡。虽然假单胞菌感染可能表现为水疱大疱性皮疹，但据信这是首例表现为葡萄球菌烫伤样皮肤综合征的新生儿恶臭假单胞菌败血症病例。
