Department of Gynecology and Obstetrics, University Medicine Göttingen, 37075 Göttingen, Germany.
Cells. 2021 Feb 18;10(2):437. doi: 10.3390/cells10020437.
The hypothalamus-pituitary-gonadal (HPG) axis is the endocrine regulation system that controls the woman's cycle. The gonadotropin-releasing hormone (GnRH) plays the central role. In addition to the gonadotrophic cells of the pituitary, GnRH receptors are expressed in other reproductive organs, such as the ovary and in tumors originating from the ovary. In ovarian cancer, GnRH is involved in the regulation of proliferation and metastasis. The effects on ovarian tumors can be indirect or direct. GnRH acts indirectly via the HPG axis and directly via GnRH receptors on the surface of ovarian cancer cells. In this systematic review, we will give an overview of the role of GnRH in ovarian cancer development, progression and therapy.
下丘脑-垂体-性腺（HPG）轴是控制女性周期的内分泌调节系统。促性腺激素释放激素（GnRH）起着核心作用。除了垂体的促性腺细胞外，GnRH 受体还在其他生殖器官中表达，如卵巢和源自卵巢的肿瘤中。在卵巢癌中，GnRH 参与了增殖和转移的调节。对卵巢肿瘤的影响可以是间接的，也可以是直接的。GnRH 通过 HPG 轴间接作用，通过卵巢癌细胞表面的 GnRH 受体直接作用。在本系统评价中，我们将概述 GnRH 在卵巢癌发展、进展和治疗中的作用。
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