PhD Program in Science Engineering and Technology, Nazarbayev University, Nur-Sultan 010000, Kazakhstan.
Department of Biology, School of Sciences and Humanities, Nazarbayev University, Nur-Sultan 010000, Kazakhstan.
Int J Mol Sci. 2021 Feb 28;22(5):2426. doi: 10.3390/ijms22052426.
Rheumatoid arthritis (RA) is a chronic autoimmune disease causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available options for patient treatment. The Collagen Triple Helix Repeat Containing 1 protein (CTHRC1) may have an important role as a biomarker for rheumatoid arthritis, as CTHRC1 protein concentration is significantly elevated in the peripheral blood of rheumatoid arthritis patients compared to osteoarthritis (OA) patients and healthy individuals. CTHRC1 is a secreted glycoprotein that promotes cell migration and has been implicated in arterial tissue-repair processes. Furthermore, high expression is observed in many types of cancer and is associated with cancer metastasis to the bone and poor patient prognosis. However, the function of CTHRC1 in RA is still largely undefined. The aim of this review is to summarize recent findings on the role of CTHRC1 as a potential biomarker and pathogenic driver of RA progression. We will discuss emerging evidence linking CTHRC1 to the pathogenic behavior of fibroblast-like synoviocytes and to cartilage and bone erosion through modulation of the balance between bone resorption and repair.
类风湿关节炎（RA）是一种慢性自身免疫性疾病，可导致关节炎症、软骨破坏和骨质侵蚀。目前正在积极寻找生物标志物和新的药物靶点，以改善患者的治疗选择。胶原三螺旋重复含 1 蛋白（CTHRC1）可能作为类风湿关节炎的一个重要生物标志物，因为与骨关节炎（OA）患者和健康个体相比，类风湿关节炎患者的外周血中 CTHRC1 蛋白浓度显著升高。CTHRC1 是一种分泌型糖蛋白，可促进细胞迁移，并与动脉组织修复过程有关。此外，在许多类型的癌症中观察到高表达，并与癌症转移至骨骼和患者预后不良有关。然而，CTHRC1 在 RA 中的功能仍在很大程度上未被定义。本综述的目的是总结最近关于 CTHRC1 作为潜在生物标志物和 RA 进展的致病性驱动因素的研究结果。我们将讨论将 CTHRC1 与成纤维样滑膜细胞的致病性行为以及通过调节骨吸收和修复之间的平衡与软骨和骨质侵蚀联系起来的新证据。
