Department of Nursing, Physiotherapy and Medicine, University of Almería, 04120 Almería, Spain.
Nursing Department, Torrecardenas Hospital, 04009 Almeria, Spain.
Int J Environ Res Public Health. 2021 Feb 28;18(5):2355. doi: 10.3390/ijerph18052355.
Although there are studies that show that some pesticides produce gonadal dysfunction and gonadal cancer in different animals, there are not many studiesregardinghumans. This study determined the prevalence and risk in humans of developing ovarian or testicular dysfunction or cancer in areas with distinct exposure to pesticides, which have endocrine disrupting properties. A population-based case-control study was carried out on humans living in ten health districts of Andalusia (Southern Spain) classified as areas of high or low environmental exposure to pesticides according to agronomic criteria. The study population included 5332 cases and 13,606 controls. Data were collected from computerized hospital records between 2000 and 2018.The risk of gonadal dysfunction or cancer was significantly higher in areas with higher use of pesticides in relation to those with lower use.
虽然有研究表明，某些农药会在不同动物中引起性腺功能障碍和性腺癌，但针对人类的研究并不多。本研究旨在确定在具有内分泌干扰特性的不同农药暴露地区，人类发生卵巢或睾丸功能障碍或癌症的患病率和风险。本研究采用基于人群的病例对照设计，在西班牙南部安达卢西亚的十个卫生区开展，根据农业标准将这些卫生区分为高或低环境农药暴露区。研究人群包括 5332 例病例和 13606 例对照。研究数据来自 2000 年至 2018 年的计算机化医院记录。与低用量地区相比，高用量地区的性腺功能障碍或癌症风险显著更高。
