Torrecárdenas University Hospital, Calle Hermandad de Donantes de Sangre, s/n 04009, Almería, Spain; Research Group CTS-1114 Health Sciences, University of Almeria, Almeria, Spain.
Research Group CTS-1114 Health Sciences, University of Almeria, Almeria, Spain; Faculty of Health Sciences, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera Sacramento s/n, La Cañada 04120 Almeria, Spain; Health Research Center, University of Almeria, Carretera Sacramento s/n, La Cañada 04120, Spain.
Psychiatry Res. 2024 Jul;337:115932. doi: 10.1016/j.psychres.2024.115932. Epub 2024 Apr 27.
The intensive cultivation under plastic in southern Spain has made the agricultural model highly productive. Although strict regulations on pesticide usage exist, exposure to pesticides in the environment has been associated with an increased appearance of neurodegenerative diseases including Alzheimer's disease (AD). A cross-sectional study was performed to examine the prevalence and risk of AD related to pesticide exposure in Andalusia (Spain). We utilized the Odds Ratio statistical test to compare the prevalence rate of AD in the exposed and unexposed areas. 40,044 cases were collected from computerized hospital records between 2000 and 2021. Districts with higher pesticide use showed significantly higher prevalence rates and increased risk of developing AD, compared to those with lower pesticide use. These findings provide further evidence supporting an increased risk of AD following environmental exposure to pesticides at the level of the general population.
西班牙南部的集约化塑料种植使得农业模式具有很高的生产力。尽管存在严格的农药使用规定，但环境中的农药暴露与神经退行性疾病（包括阿尔茨海默病（AD））的发病率增加有关。进行了一项横断面研究，以检查在安达卢西亚（西班牙）与农药暴露有关的 AD 患病率和风险。我们利用优势比统计检验来比较暴露和未暴露地区的 AD 患病率。在 2000 年至 2021 年期间，从计算机化的医院记录中收集了 40044 例病例。与农药使用较少的地区相比，农药使用较多的地区的 AD 患病率显著更高，且患 AD 的风险增加。这些发现为在普通人群中环境暴露于农药会增加 AD 风险提供了进一步的证据。
