Rueda-Ruzafa Lola, Roman Pablo, Cardona Diana, Requena Mar, Ropero-Padilla Carmen, Alarcón Raquel
Faculty of Health Sciences, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera Sacramento S/N, La Cañada, 04120 Almeria, Spain.
Faculty of Health Sciences, Department of Nursing, Physiotherapy and Medicine, University of Almeria, Carretera Sacramento S/N, La Cañada, 04120 Almeria, Spain; Health Research Center, University of Almeria, Carretera Sacramento S/N, La Cañada 04120, Spain.
Environ Toxicol Pharmacol. 2023 Mar;98:104076. doi: 10.1016/j.etap.2023.104076. Epub 2023 Feb 7.
The agricultural model in southern Spain is highly productive, mainly due to the intensive cultivation under plastic. Despite strict pesticide regulation, human exposure to pesticides in the environment has been connected to an increase in diseases such as celiac disease. Certain pesticides have also been associated to the disruption of the intestinal microbiota, which has been tied to the development of irritable bowel syndrome (IBS). A case-control study was conducted in Andalusia, south Spain, to assess the prevalence and risk of IBS related to pesticide exposure. This research found a high prevalence of IBS in Andalusia between 2000 and 2021 in areas with high pesticide exposure using agronomic criteria. Furthermore, the odds ratio for IBS was significantly higher in the population with high pesticide exposure. This study suggests that pesticides may be involved in IBS, whereas more research is needed to determine the role of pesticides in IBS symptomatology.
西班牙南部的农业模式生产力很高，这主要归功于塑料大棚下的集约化种植。尽管有严格的农药监管，但人类在环境中接触农药与乳糜泻等疾病的增加有关。某些农药还与肠道微生物群的破坏有关，而这又与肠易激综合征（IBS）的发展有关。在西班牙南部的安达卢西亚进行了一项病例对照研究，以评估与接触农药相关的IBS的患病率和风险。这项研究发现，根据农艺标准，2000年至2021年期间，安达卢西亚农药高暴露地区的IBS患病率很高。此外，农药高暴露人群患IBS的比值比显著更高。这项研究表明，农药可能与IBS有关，不过还需要更多研究来确定农药在IBS症状学中的作用。
