Brain Mechanisms for Behaviour Unit, Okinawa Institute of Science and Technology, Graduate University, Onna-son, Okinawa 904-0495, Japan.
Cells. 2021 Feb 28;10(3):513. doi: 10.3390/cells10030513.
I feel part of a massive effort to understand what is wrong with motor systems in the brain relating to Parkinson's disease. Today, the symptoms of the disease can be modified slightly, but dopamine neurons still die; the disease progression continues inexorably. Maybe the next research phase will bring the power of modern genetics to bear on halting, or better, preventing cell death. The arrival of accessible human neuron assemblies in organoids perhaps will provide a better access to the processes underlying neuronal demise.
我觉得自己是一项重大研究的一部分，该研究旨在深入了解与帕金森病相关的大脑运动系统出了什么问题。目前，虽然可以稍微改善这种疾病的症状，但多巴胺神经元仍在死亡；疾病仍在无情地发展。也许下一阶段的研究将利用现代遗传学的力量来阻止，或者更好的是，预防细胞死亡。类器官中可获取的人类神经元集合体的出现，或许将为深入研究神经元死亡的背后过程提供更好的途径。
