良性阵发性位置性眩晕与甲状腺疾病关系的分析：一项巢式病例对照研究。
Analyses of the Relation between BPPV and Thyroid Diseases: A Nested Case-Control Study.
作者信息
Choi Hyo Geun, Song Young Shin, Wee Jee Hye, Min Chanyang, Yoo Dae Myoung, Kim So Young
机构信息
Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang 14068, Korea.
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea.
出版信息
Diagnostics (Basel). 2021 Feb 17;11(2):329. doi: 10.3390/diagnostics11020329.
BACKGROUND
This study investigated relationship between multiple thyroid disorders and benign paroxysmal positional vertigo (BPPV), adjusting for levothyroxine medication.
METHODS
The Korean National Health Insurance Service-Health Screening Cohort data from 2002 to 2015 were used. A total of 19,071 patients with BPPV were matched with 76,284 participants of a control group in a ratio of 1:4 for age, sex, income, and region of residence. The previous histories of thyroid disorders such as goiter, hypothyroidism, thyroiditis, hyperthyroidism, and autoimmune thyroiditis were investigated in both the BPPV and control groups. The odds ratios (ORs) for BPPV in thyroid diseases were calculated using conditional logistic regression analyses.
RESULTS
The histories of goiter (5.5% vs. 4.1%), hypothyroidism (4.7% vs. 3.7%), thyroiditis (2.1% vs. 1.6%), and hyperthyroidism (3.1% vs. 2.5%) were higher in the BPPV group than in the control group (all < 0.001). Goiter, hypothyroidism, thyroiditis, and hyperthyroidism were associated with BPPV (adjusted OR = 1.28 (95% CI = 1.17-1.39) for goiter, 1.23 (95% CI = 1.10-1.37) for hypothyroidism, 1.13 (95% CI = 1.02-1.26) for hyperthyroidism, each < 0.05).
CONCLUSIONS
BPPV was associated with thyroid disorders such as goiter, hypothyroidism, thyroiditis, and hyperthyroidism.
背景
本研究在调整左甲状腺素用药的情况下，调查了多种甲状腺疾病与良性阵发性位置性眩晕（BPPV）之间的关系。
方法
使用了2002年至2015年韩国国民健康保险服务健康筛查队列数据。总共19071例BPPV患者与76284名对照组参与者按年龄、性别、收入和居住地区以1:4的比例进行匹配。在BPPV组和对照组中均调查了甲状腺疾病的既往史，如甲状腺肿、甲状腺功能减退、甲状腺炎、甲状腺功能亢进和自身免疫性甲状腺炎。使用条件逻辑回归分析计算甲状腺疾病中BPPV的优势比（OR）。
结果
BPPV组甲状腺肿（5.5%对4.1%）、甲状腺功能减退（4.7%对3.7%）、甲状腺炎（2.1%对1.6%）和甲状腺功能亢进（3.1%对2.5%）的病史高于对照组（均P<0.001）。甲状腺肿、甲状腺功能减退、甲状腺炎和甲状腺功能亢进与BPPV相关（甲状腺肿调整后的OR = 1.28（95%CI = 1.17 - 1.39），甲状腺功能减退为1.23（95%CI = 1.10 - 1.37），甲状腺功能亢进为1.13（95%CI = 1.02 - 1.26），均P<0.05）。
结论
BPPV与甲状腺疾病如甲状腺肿、甲状腺功能减退、甲状腺炎和甲状腺功能亢进相关。
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