Department of Otorhinolaryngology-Head and Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Sci Rep. 2020 Oct 26;10(1):18224. doi: 10.1038/s41598-020-75404-y.
The association of thyroid disease and Ménière's disease would suggest that both are autoimmune diseases. This study aimed to investigate the relation of goiter, hypothyroidism, thyroiditis, hyperthyroidism, and autoimmune thyroiditis with Ménière's disease. The Korean National Health Insurance Service-Health Screening Cohort data from 2002 through 2015 were used. The 8183 adult patients with Ménière's disease were 1:4 matched with the 32,732 individuals of the control group for age, sex, income, and region of residence. The previous histories of thyroid disorders including goiter, hypothyroidism, thyroiditis, and hyperthyroidism were investigated using conditional logistic regression analyses. Subgroup analyses were conducted, including for age and sex. Smoking, alcohol consumption, obesity, Charlson Comorbidity Index, histories of benign paroxysmal vertigo, vestibular neuronitis, other peripheral vertigo, thyroid cancer, and levothyroxine medication were adjusted in the models. The histories of goiter (5.7% vs. 4.2%), hypothyroidism (4.7% vs. 3.6%), thyroiditis (2.1% vs. 1.6%), hyperthyroidism (3.6% vs. 2.5%), and autoimmune thyroiditis (0.99% vs. 0.67%) were higher in the Meniere's disease group than in the control group (all P < 0.05). The histories of goiter, hypothyroidism, and hyperthyroidism were associated with Ménière's disease (adjusted odds ratio (OR) = 1.19 [95% confidence interval (CI) = 1.04-1.36] for goiter, 1.21 [95% CI 1.02-1.44] for hypothyroidism, and 1.27 [95% CI 1.09-1.49] for hyperthyroidism, each of P < 0.05). In subgroup analyses, hypothyroidism was associated with Ménière's disease in < 65-year-old women. Hyperthyroidism was related with Ménière's disease in women overall. Thyroid diseases of goiter, hypothyroidism, and hyperthyroidism were associated with Ménière's disease.
甲状腺疾病与梅尼埃病的关联表明两者都是自身免疫性疾病。本研究旨在探讨甲状腺肿、甲状腺功能减退症、甲状腺炎、甲状腺功能亢进症和自身免疫性甲状腺炎与梅尼埃病的关系。使用了 2002 年至 2015 年的韩国国家健康保险服务-健康筛查队列数据。8183 例成人梅尼埃病患者按年龄、性别、收入和居住地与 32732 名对照组个体进行 1:4 匹配。使用条件逻辑回归分析调查了甲状腺疾病（包括甲状腺肿、甲状腺功能减退症、甲状腺炎和甲状腺功能亢进症）的既往史。进行了亚组分析，包括年龄和性别。在模型中调整了吸烟、饮酒、肥胖、Charlson 合并症指数、良性阵发性眩晕、前庭神经元炎、其他周围性眩晕、甲状腺癌和左甲状腺素治疗的历史。梅尼埃病组的甲状腺肿（5.7%比 4.2%）、甲状腺功能减退症（4.7%比 3.6%）、甲状腺炎（2.1%比 1.6%）、甲状腺功能亢进症（3.6%比 2.5%）和自身免疫性甲状腺炎（0.99%比 0.67%）的既往史高于对照组（均 P<0.05）。甲状腺肿、甲状腺功能减退症和甲状腺功能亢进症的病史与梅尼埃病相关（甲状腺肿的调整优势比（OR）=1.19[95%置信区间（CI）1.04-1.36]，甲状腺功能减退症的 OR=1.21[95%CI 1.02-1.44]，甲状腺功能亢进症的 OR=1.27[95%CI 1.09-1.49]，均 P<0.05）。在亚组分析中，<65 岁女性的甲状腺功能减退症与梅尼埃病相关。甲状腺功能亢进症与所有女性的梅尼埃病有关。甲状腺肿、甲状腺功能减退症和甲状腺功能亢进症等甲状腺疾病与梅尼埃病有关。
