CHA Bundang Medical Center, Department of Otorhinolaryngology-Head & Neck Surgery, CHA University, Seongnam 13496, Korea.
CHA Bundang Medical Center, Department of Internal Medicine, CHA University, Seongnam 13496, Korea.
Int J Environ Res Public Health. 2020 Nov 13;17(22):8419. doi: 10.3390/ijerph17228419.
The association between thyroid disease and sudden sensorineural hearing loss (SSNHL) has not been evaluated. We investigated the association of goiter, hypothyroidism, thyroiditis, and hyperthyroidism with sudden sensorineural hearing loss (SSNHL). Data from the Korean National Health Insurance Service-Health Screening Cohort were used. The 8658 SSNHL patients were matched in a 1:4 ratio with 34,632 controls for age, sex, and region of residence. Histories of goiter, hypothyroidism, thyroiditis, hyperthyroidism, and Levothyroxine medication were explored as possible factors influencing SSNHL development. Associations were estimated using conditional logistic regression analyses, adjusted for Levothyroxine medication use. Subgroup analyses were conducted according to age, sex, income, and region of residence. SSNHL patients had a higher rate of goiter occurrence (4.4% vs. 3.7 %, = 0.001) and hypothyroidism (4.0% vs. 3.2 %, < 0.001) than controls. Goiter and hypothyroidism were positively associated with SSNHL (adjusted OR =1.14 (95% CI =1.01-1.28), = 0.043 for goiter and 1.17 (95% CI =1.03-1.33), = 0.016 for hypothyroidism). In subgroup analyses, hypothyroidism or goiter was more prevalent in SSNHL patients than in controls. Lower-income subgroups showed associations of hypothyroidism and goiter with SSNHL. SSNHL patients were more likely to have goiter and hypothyroidism than normal individuals.
甲状腺疾病与突发性聋（SSNHL）之间的关系尚未得到评估。我们调查了甲状腺肿、甲状腺功能减退症、甲状腺炎和甲状腺功能亢进症与突发性聋（SSNHL）之间的关系。使用了韩国国民健康保险服务-健康筛查队列的数据。8658 例 SSNHL 患者与 34632 例年龄、性别和居住地相匹配的对照组进行 1:4 配对。探讨了甲状腺肿、甲状腺功能减退症、甲状腺炎、甲状腺功能亢进症和左甲状腺素治疗的病史是否为影响 SSNHL 发生的可能因素。使用条件逻辑回归分析估计关联，并调整了左甲状腺素的使用情况。根据年龄、性别、收入和居住地进行了亚组分析。SSNHL 患者甲状腺肿发生率（4.4% vs. 3.7%， = 0.001）和甲状腺功能减退症发生率（4.0% vs. 3.2%， < 0.001）均高于对照组。甲状腺肿和甲状腺功能减退症与 SSNHL 呈正相关（调整后的 OR =1.14（95%CI =1.01-1.28）， = 0.043 对于甲状腺肿和 1.17（95%CI =1.03-1.33）， = 0.016 对于甲状腺功能减退症）。在亚组分析中，SSNHL 患者中甲状腺功能减退症或甲状腺肿的发生率高于对照组。收入较低的亚组中，甲状腺功能减退症和甲状腺肿与 SSNHL 之间存在关联。SSNHL 患者比正常人更有可能患有甲状腺肿和甲状腺功能减退症。
