胶质瘤不同阶段ETS结构域转录因子的基因调控网络
Gene Regulatory Network of ETS Domain Transcription Factors in Different Stages of Glioma.
作者信息
Babal Yigit Koray, Kandemir Basak, Kurnaz Isil Aksan
机构信息
Institute of Biotechnology, Gebze Technical University, 41400 Gebze, Kocaeli, Turkey.
Department of Molecular Biology and Genetics, Baskent University, 06790 Ankara, Turkey.
出版信息
J Pers Med. 2021 Feb 17;11(2):138. doi: 10.3390/jpm11020138.
Abstract
The ETS domain family of transcription factors is involved in a number of biological processes, and is commonly misregulated in various forms of cancer. Using microarray datasets from patients with different grades of glioma, we have analyzed the expression profiles of various genes, and have identified and as novel biomarkers for the identification of different glioma grades. We have further analyzed the gene regulatory networks of ETS transcription factors and compared them to previous microarray studies, where Elk-1-VP16 or PEA3-VP16 were overexpressed in neuroblastoma cell lines, and we identify unique and common regulatory networks for these ETS proteins.
摘要
ETS转录因子家族参与多种生物学过程，在各种癌症中通常存在调控异常。利用来自不同级别胶质瘤患者的微阵列数据集，我们分析了各种基因的表达谱，并鉴定出[具体基因1]和[具体基因2]作为鉴定不同胶质瘤级别的新型生物标志物。我们进一步分析了ETS转录因子的基因调控网络，并将其与之前的微阵列研究进行比较，在之前的研究中，Elk-1-VP16或PEA3-VP16在神经母细胞瘤细胞系中过表达，我们确定了这些ETS蛋白独特和共同的调控网络。
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