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一种益生菌产品对高强度和长时间体育锻炼诱导的氧化应激模型的抗氧化作用。

Antioxidant Effect of a Probiotic Product on a Model of Oxidative Stress Induced by High-Intensity and Duration Physical Exercise.

作者信息

Sánchez Macarro Maravillas, Ávila-Gandía Vicente, Pérez-Piñero Silvia, Cánovas Fernando, García-Muñoz Ana María, Abellán-Ruiz María Salud, Victoria-Montesinos Desirée, Luque-Rubia Antonio J, Climent Eric, Genovés Salvador, Ramon Daniel, Chenoll Empar, López-Román Francisco Javier

机构信息

Department of Exercise Physiology, San Antonio Catholic University of Murcia (UCAM), 30107 Murcia, Spain.

Research and Development Department, ADM-Biopolis, ADM, Parc Cientific Universitat de Valencia, Paterna, 46980 Valencia, Spain.

出版信息

Antioxidants (Basel). 2021 Feb 22;10(2):323. doi: 10.3390/antiox10020323.

DOI:10.3390/antiox10020323
PMID:33671691
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7926771/
Abstract

This randomized double-blind and controlled single-center clinical trial was designed to evaluate the effect of a 6-week intake of a probiotic product (1 capsule/day) vs. a placebo on an oxidative stress model of physical exercise (high intensity and duration) in male cyclists (probiotic group, = 22; placebo, = 21). This probiotic included three lyophilized strains ( CECT 7347, CECT 9104, and CECT 8361). Study variables were urinary isoprostane, serum malondialdehyde (MDA), serum oxidized low-density lipoprotein (Ox-LDL), urinary 8-hydroxy-2'-deoxiguanosine (8-OHdG), serum protein carbonyl, serum glutathione peroxidase (GPx), and serum superoxide dismutase (SOD). At 6 weeks, as compared with baseline, significant differences in 8-OHdG (Δ mean difference -10.9 (95% CI -14.5 to -7.3); < 0.001), MDA (Δ mean difference -207.6 (95% CI -349.1 to -66.1; < 0.05), and Ox-LDL (Δ mean difference -122.5 (95% CI -240 to -4.5); < 0.05) were found in the probiotic group only. Serum GPx did not increase in the probiotic group, whereas the mean difference was significant in the placebo group (477.8 (95% CI 112.5 to 843.2); < 0.05). These findings suggest an antioxidant effect of this probiotic on underlying interacting oxidative stress mechanisms and their modulation in healthy subjects. The study was registered in ClinicalTrials.gov (NCT03798821).

摘要

这项随机双盲单中心对照临床试验旨在评估男性自行车运动员（益生菌组，n = 22；安慰剂组，n = 21）服用6周益生菌产品（每日1粒胶囊）与服用安慰剂相比，对高强度和长时间体育锻炼氧化应激模型的影响。该益生菌包含三种冻干菌株（CECT 7347、CECT 9104和CECT 8361）。研究变量包括尿异前列腺素、血清丙二醛（MDA）、血清氧化型低密度脂蛋白（Ox-LDL）、尿8-羟基-2'-脱氧鸟苷（8-OHdG）、血清蛋白羰基、血清谷胱甘肽过氧化物酶（GPx）和血清超氧化物歧化酶（SOD）。6周时，与基线相比，仅在益生菌组中发现8-OHdG（平均差异Δ -10.9（95%CI -14.5至-7.3）；P < 0.001）、MDA（平均差异Δ -207.6（95%CI -349.1至-66.1；P < 0.05）和Ox-LDL（平均差异Δ -122.5（95%CI -240至-4.5）；P < 0.05）有显著差异。益生菌组血清GPx未增加，而安慰剂组平均差异显著（477.8（95%CI 112.5至843.2）；P < 0.05）。这些发现表明该益生菌对健康受试者潜在的相互作用氧化应激机制及其调节具有抗氧化作用。该研究已在ClinicalTrials.gov（NCT03798821）注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49b/7926771/117594228770/antioxidants-10-00323-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49b/7926771/312c15336102/antioxidants-10-00323-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49b/7926771/6496c34929d5/antioxidants-10-00323-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49b/7926771/534046289945/antioxidants-10-00323-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49b/7926771/117594228770/antioxidants-10-00323-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49b/7926771/312c15336102/antioxidants-10-00323-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49b/7926771/6496c34929d5/antioxidants-10-00323-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49b/7926771/534046289945/antioxidants-10-00323-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b49b/7926771/117594228770/antioxidants-10-00323-g004.jpg

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