Mohammadi Ali Akbar, Jazayeri Shima, Khosravi-Darani Kianoush, Solati Zahra, Mohammadpour Nakisa, Asemi Zatollah, Adab Zohre, Djalali Mahmoud, Tehrani-Doost Mehdi, Hosseini Mostafa, Eghtesadi Shahryar
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Research Department of Food Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Int J Prev Med. 2015 Sep 1;6:82. doi: 10.4103/2008-7802.164146. eCollection 2015.
The aim of the current study was to determine effects of probiotic yoghurt and multispecies probiotic capsule supplementation on biomarkers of oxidative stress and inflammatory factors in petrochemical workers.
This randomized, double-blind, placebo-controlled trial was done among petrochemical workers. Subjects were randomly divided into three groups to receive 100 g/day probiotic yogurt (n = 12) or one probiotic capsule daily (n = 13) or 100 g/day conventional yogurt (n = 10) for 6 weeks. The probiotic yoghurt was containing two strains of Lactobacillus acidophilus and Bifidobacterium lactis with a total of min 1 × 10(7) CFU. Multispecies probiotic capsule contains seven probiotic bacteria spices Actobacillus casei 3 × 10(3), L. acidophilus 3 × 10(7), Lactobacillus rhamnosus 7 × 10(9), Lactobacillus bulgaricus 5 × 10(8), Bifidobacterium breve 2 × 10(10), Bifidobacterium longum 1 × 10(9) and Streptococcus thermophilus 3 × 10(8) CFU/g. Fasting blood samples were obtained at the beginning and end of the trial to quantify biomarkers of oxidative stress and inflammatory factors.
Although a significant within-group decrease in plasma protein carbonyl levels was seen in the probiotic capsule group (326.0 ± 308.9 vs. 251.0 ± 176.3 ng/mL, P = 0.02), the changes were similar among the three groups. In addition, significant within-group decreases in plasma iso prostaglandin were observed in the probiotic supplements group (111.9 ± 85.4 vs. 88.0 ± 71.0 pg/mL, P = 0.003) and in the probiotic yogurt group (116.3 ± 93.0 vs. 92.0 ± 66.0 pg/mL, P = 0.02), nevertheless there were no significant change among the three groups.
Taken together, consumption of probiotic yogurt or multispecies probiotic capsule had beneficial effects on biomarkers of oxidative stress in petrochemical workers.
本研究旨在确定补充益生菌酸奶和多菌株益生菌胶囊对石化行业工人氧化应激生物标志物和炎症因子的影响。
本随机、双盲、安慰剂对照试验在石化行业工人中进行。受试者被随机分为三组，分别接受每天100克益生菌酸奶（n = 12）、每天一粒益生菌胶囊（n = 13）或每天100克传统酸奶（n = 10），持续6周。益生菌酸奶含有嗜酸乳杆菌和双歧杆菌两株菌，总数至少为1×10⁷CFU。多菌株益生菌胶囊含有七种益生菌菌株，干酪乳杆菌3×10³、嗜酸乳杆菌3×10⁷、鼠李糖乳杆菌7×10⁹、保加利亚乳杆菌5×10⁸、短双歧杆菌2×10¹⁰、长双歧杆菌1×10⁹和嗜热链球菌3×10⁸CFU/g。在试验开始和结束时采集空腹血样，以量化氧化应激生物标志物和炎症因子。
虽然益生菌胶囊组血浆蛋白羰基水平在组内显著下降（326.0±308.9对251.0±176.3 ng/mL，P = 0.02），但三组间变化相似。此外，益生菌补充剂组（111.9±85.4对88.0±71.0 pg/mL，P = 0.003）和益生菌酸奶组（116.3±93.0对92.0±66.0 pg/mL，P = 0.02）血浆异前列腺素在组内显著下降，然而三组间无显著变化。
综上所述，食用益生菌酸奶或多菌株益生菌胶囊对石化行业工人的氧化应激生物标志物有有益影响。
