Tulbă Delia, Cozma Liviu, Bălănescu Paul, Buzea Adrian, Băicuș Cristian, Popescu Bogdan Ovidiu
Department of Neurology, Colentina Clinical Hospital, 20125 Bucharest, Romania.
Colentina-Research and Development Center, Colentina Clinical Hospital, 20125 Bucharest, Romania.
J Pers Med. 2021 Feb 15;11(2):129. doi: 10.3390/jpm11020129.
(1) Background: Cardiovascular autonomic dysfunction is a non-motor feature in Parkinson's disease with negative impact on functionality and life expectancy, prompting early detection and proper management. We aimed to describe the blood pressure patterns reported in patients with Parkinson's disease, as measured by 24-h ambulatory blood pressure monitoring. (2) Methods: We conducted a systematic search on the PubMed database. Studies enrolling patients with Parkinson's disease undergoing 24-h ambulatory blood pressure monitoring were included. Data regarding study population, Parkinson's disease course, vasoactive drugs, blood pressure profiles, and measurements were recorded. (3) Results: The search identified 172 studies. Forty studies eventually fulfilled the inclusion criteria, with 3090 patients enrolled. Abnormal blood pressure profiles were commonly encountered: high blood pressure in 38.13% of patients (938/2460), orthostatic hypotension in 38.68% (941/2433), supine hypertension in 27.76% (445/1603) and nocturnal hypertension in 38.91% (737/1894). Dipping status was also altered often, 40.46% of patients (477/1179) being reverse dippers and 35.67% (310/869) reduced dippers. All these patterns were correlated with negative clinical and imaging outcomes. (4) Conclusion: Patients with Parkinson's disease have significantly altered blood pressure patterns that carry a negative prognosis. Ambulatory blood pressure monitoring should be validated as a biomarker of PD-associated cardiovascular dysautonomia and a tool for assisting therapeutic interventions.
(1) 背景：心血管自主神经功能障碍是帕金森病的一种非运动特征，对功能和预期寿命有负面影响，促使早期检测和适当管理。我们旨在描述帕金森病患者通过24小时动态血压监测所报告的血压模式。(2) 方法：我们在PubMed数据库上进行了系统检索。纳入了对帕金森病患者进行24小时动态血压监测的研究。记录了有关研究人群、帕金森病病程、血管活性药物、血压概况和测量数据。(3) 结果：检索到172项研究。最终有40项研究符合纳入标准，共纳入3090例患者。常见异常血压概况：38.13%的患者（938/2460）出现高血压，38.68%（941/2433）出现体位性低血压，27.76%（445/1603）出现仰卧位高血压，38.91%（737/1894）出现夜间高血压。血压波动状态也常发生改变，40.46%的患者（477/1179）为反勺型血压，35.67%（310/869）为勺型血压减弱。所有这些模式均与负面的临床和影像学结果相关。(4) 结论：帕金森病患者的血压模式有显著改变，预后不良。动态血压监测应被确认为帕金森病相关心血管自主神经功能障碍的生物标志物和辅助治疗干预的工具。
Zotero 插件