Alrimawi Bilal Harieth, Chan May Yee, Ooi Xin Yue, Chan Siok-Yee, Goh Choon Fu
Discipline of Pharmaceutical Technology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.
Polymers (Basel). 2021 Feb 15;13(4):578. doi: 10.3390/polym13040578.
Rice starch is a promising biomaterial for thin film development in buccal drug delivery, but the plasticisation and antiplasticisation phenomena from both plasticisers and drugs on the performance of rice starch films are not well understood. This study aims to elucidate the competing effects of sorbitol (plasticiser) and drug (antiplasticiser) on the physicochemical characteristics of rice starch films containing low paracetamol content. Rice starch films were prepared with different sorbitol (10, 20 and 30% /) and paracetamol contents (0, 1 and 2% /) using the film casting method and were characterised especially for drug release, swelling and mechanical properties. Sorbitol showed a typical plasticising effect on the control rice starch films by increasing film flexibility and by reducing swelling behaviour. The presence of drugs, however, modified both the mechanical and swelling properties by exerting an antiplasticisation effect. This antiplasticisation action was found to be significant at a low sorbitol level or a high drug content. FTIR investigations supported the antiplasticisation action of paracetamol through the disturbance of sorbitol-starch interactions. Despite this difference, an immediate drug release was generally obtained. This study highlights the interplay between plasticiser and drug in influencing the mechanical and swelling characteristics of rice starch films at varying concentrations.
大米淀粉是口腔给药薄膜开发中一种很有前景的生物材料，但增塑剂和药物对大米淀粉膜性能的增塑和反增塑现象尚未得到充分了解。本研究旨在阐明山梨醇（增塑剂）和药物（反增塑剂）对低对乙酰氨基酚含量大米淀粉膜物理化学特性的竞争作用。采用流延法制备了具有不同山梨醇含量（10%、20%和30%/）和对乙酰氨基酚含量（0%、1%和2%/）的大米淀粉膜，并特别对药物释放、溶胀和机械性能进行了表征。山梨醇对对照大米淀粉膜表现出典型的增塑作用，增加了膜的柔韧性并降低了溶胀行为。然而，药物的存在通过发挥反增塑作用改变了机械性能和溶胀性能。发现这种反增塑作用在低山梨醇水平或高药物含量时很显著。傅里叶变换红外光谱（FTIR）研究通过干扰山梨醇 - 淀粉相互作用支持了对乙酰氨基酚的反增塑作用。尽管存在这种差异，但通常能实现药物的即时释放。本研究强调了增塑剂和药物在不同浓度下对大米淀粉膜机械性能和溶胀特性影响中的相互作用。
