U733, Centre for Biomedical Network Research on Rare Diseases (CIBERER-ISCIII), 28029 Madrid, Spain.
Mixed Unit for Rare Diseases INCLIVA-CIPF, INCLIVA Health Research Institute, 46010 Valencia, Spain.
Int J Environ Res Public Health. 2021 Feb 15;18(4):1883. doi: 10.3390/ijerph18041883.
The main epigenetic features in aging are: reduced bulk levels of core histones, altered pattern of histone post-translational modifications, changes in the pattern of DNA methylation, replacement of canonical histones with histone variants, and altered expression of non-coding RNA. The identification of epigenetic mechanisms may contribute to the early detection of age-associated subclinical changes or deficits at the molecular and/or cellular level, to predict the development of frailty, or even more interestingly, to improve health trajectories in older adults. Frailty reflects a state of increased vulnerability to stressors as a result of decreased physiologic reserves, and even dysregulation of multiple physiologic systems leading to adverse health outcomes for individuals of the same chronological age. A key approach to overcome the challenges of frailty is the development of biomarkers to improve early diagnostic accuracy and to predict trajectories in older individuals. The identification of epigenetic biomarkers of frailty could provide important support for the clinical diagnosis of frailty, or more specifically, to the evaluation of its associated risks. Interventional studies aimed at delaying the onset of frailty and the functional alterations associated with it, would also undoubtedly benefit from the identification of frailty biomarkers. Specific to the article yet reasonably common within the subject discipline.
核心组蛋白的整体水平降低、组蛋白翻译后修饰模式改变、DNA 甲基化模式变化、经典组蛋白被组蛋白变体取代，以及非编码 RNA 的表达改变。识别表观遗传机制可能有助于早期发现与年龄相关的亚临床变化或分子和/或细胞水平的缺陷，预测虚弱的发展，甚至更有趣的是，改善老年人的健康轨迹。虚弱反映了一种由于生理储备减少，甚至多个生理系统失调导致同一年龄的个体健康结果不良的应激源易感性增加的状态。克服虚弱挑战的关键方法是开发生物标志物以提高早期诊断的准确性，并预测老年人的轨迹。脆弱的表观遗传生物标志物的识别可以为虚弱的临床诊断提供重要支持，或者更具体地说，为评估其相关风险提供支持。旨在延缓虚弱的发生和与之相关的功能改变的干预性研究，也无疑将受益于脆弱生物标志物的识别。特定于本文，但在学科内较为常见。
