Perez Marcos A, Watts Jennifer L
School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA.
Metabolites. 2021 Feb 23;11(2):125. doi: 10.3390/metabo11020125.
is well-known as the model organism used to elucidate the genetic pathways underlying the first described form of regulated cell death, apoptosis. Since then, investigations have contributed to the further understanding of lipids in apoptosis, especially the roles of phosphatidylserines and phosphatidylinositols. More recently, studies in have shown that dietary polyunsaturated fatty acids can induce the non-apoptotic, iron-dependent form of cell death, ferroptosis. In this review, we examine the roles of various lipids in specific aspects of regulated cell death, emphasizing recent work in .
作为用于阐明最早描述的程序性细胞死亡形式——凋亡背后遗传途径的模式生物而广为人知。从那时起，研究有助于进一步理解脂质在凋亡中的作用，特别是磷脂酰丝氨酸和磷脂酰肌醇的作用。最近，在……的研究表明，膳食多不饱和脂肪酸可诱导非凋亡性、铁依赖性细胞死亡形式——铁死亡。在本综述中，我们研究了各种脂质在程序性细胞死亡特定方面的作用，重点介绍了在……方面的最新研究工作。
