壳聚糖和透明质酸在医学中的多功能应用。
Versatile Use of Chitosan and Hyaluronan in Medicine.
机构信息
Centre of Experimental Medicine, Slovak Academy of Sciences, Dúbravská Cesta 9, 84104 Bratislava, Slovakia.
出版信息
Molecules. 2021 Feb 23;26(4):1195. doi: 10.3390/molecules26041195.
Abstract
Chitosan is industrially acquired by the alkaline -deacetylation of chitin. Chitin belongs to the β--acetyl-glucosamine polymers, providing structure, contrary to α-polymers, which provide food and energy. Another β-polymer providing structure is hyaluronan. A lot of studies have been performed on chitosan to explore its industrial use. Since chitosan is biodegradable, non-toxic, bacteriostatic, and fungistatic, it has numerous applications in medicine. Hyaluronan, one of the major structural components of the extracellular matrix in vertebrate tissues, is broadly exploited in medicine as well. This review summarizes the main areas where these two biopolymers have an impact. The reviewed areas mostly cover most medical applications, along with non-medical applications, such as cosmetics.
摘要
壳聚糖是通过甲壳素的碱性脱乙酰化作用获得的。甲壳素属于β-乙酰氨基葡萄糖聚合物，提供结构，与提供食物和能量的α-聚合物相反。另一种提供结构的β-聚合物是透明质酸。人们对壳聚糖进行了大量研究，以探索其工业用途。由于壳聚糖可生物降解、无毒、抑菌和抗真菌，因此在医学中有许多应用。透明质酸是脊椎动物组织细胞外基质的主要结构成分之一，在医学中也有广泛的应用。这篇综述总结了这两种生物聚合物的主要影响领域。综述的领域主要涵盖了大多数医学应用，以及非医学应用，如化妆品。
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