Budai Lívia, Budai Marianna, Fülöpné Pápay Zsófia Edit, Vilimi Zsófia, Antal István
Department of Pharmaceutics, Semmelweis University, 1092 Budapest, Hungary.
Gels. 2023 Jun 7;9(6):469. doi: 10.3390/gels9060469.
Controlling rheological properties offers the opportunity to gain insight into the physical characteristics, structure, stability and drug release rate of formulations. To better understand the physical properties of hydrogels, not only rotational but also oscillatory experiments should be performed. Viscoelastic properties, including elastic and viscous properties, are measured using oscillatory rheology. The gel strength and elasticity of hydrogels are of great importance for pharmaceutical development as the application of viscoelastic preparations has considerably expanded in recent decades. Viscosupplementation, ophthalmic surgery and tissue engineering are just a few examples from the wide range of possible applications of viscoelastic hydrogels. Hyaluronic acid, alginate, gellan gum, pectin and chitosan are remarkable representatives of gelling agents that attract great attention applied in biomedical fields. This review provides a brief summary of rheological properties, highlighting the viscoelasticity of hydrogels with great potential in biomedicine.
控制流变学性质为深入了解制剂的物理特性、结构、稳定性和药物释放速率提供了契机。为了更好地理解水凝胶的物理性质，不仅应进行旋转实验，还应进行振荡实验。使用振荡流变学测量包括弹性和粘性在内的粘弹性性质。水凝胶的凝胶强度和弹性对药物研发非常重要，因为近几十年来粘弹性制剂的应用有了显著扩展。粘弹性补充疗法、眼科手术和组织工程只是粘弹性水凝胶众多可能应用中的几个例子。透明质酸、藻酸盐、结冷胶、果胶和壳聚糖是在生物医学领域应用中备受关注的胶凝剂的显著代表。本综述简要总结了流变学性质，重点介绍了在生物医学中具有巨大潜力的水凝胶的粘弹性。
