Department of Biological Sciences, Brock University, 1812 Sir Isaac brock Way, St. Catharines, ON L2S 3A1, Canada.
Centre for Neuroscience, Brock University, 1812 Sir Isaac brock Way, St. Catharines, ON L2S 3A1, Canada.
Int J Mol Sci. 2021 Feb 20;22(4):2103. doi: 10.3390/ijms22042103.
Cannabis has long been used for its medicinal and psychoactive properties. With the relatively new adoption of formal medicinal cannabis regulations worldwide, the study of cannabinoids, both endogenous and exogenous, has similarly flourished in more recent decades. In particular, research investigating the role of cannabinoids in regeneration and neurodevelopment has yielded promising results in vertebrate models. However, regeneration-competent vertebrates are few, whereas a myriad of invertebrate species have been established as superb models for regeneration. As such, this review aims to provide a comprehensive summary of the endocannabinoid system, with a focus on current advances in the area of endocannabinoid system contributions to invertebrate neurodevelopment and regeneration.
大麻长期以来因其药用和精神活性特性而被使用。随着全球对正式药用大麻法规的相对较新采用，内源性和外源性大麻素的研究在最近几十年也同样蓬勃发展。特别是，研究大麻素在再生和神经发育中的作用在脊椎动物模型中产生了有希望的结果。然而，再生能力强的脊椎动物很少，而有许多已被确立为再生的优秀模型的无脊椎动物物种。因此，本综述旨在全面总结内源性大麻素系统，并重点介绍内源性大麻素系统对无脊椎动物神经发育和再生贡献的最新进展。
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