Rasulova Madina, Zečić Aleksandra, Monje Moreno Jose Manuel, Vandemeulebroucke Lieselot, Dhondt Ineke, Braeckman Bart P
Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.
Metabolites. 2021 Feb 12;11(2):105. doi: 10.3390/metabo11020105.
The insulin/IGF-1 (insulin-like growth factor 1) signaling mutant recapitulates the dauer metabolic signature-a shift towards lipid and carbohydrate accumulation-which may be linked to its longevity and stress resistance phenotypes. Trehalose, a disaccharide of glucose, is highly upregulated in mutants and it has been linked to proteome stabilization and protection against heat, cold, desiccation, and hypoxia. Earlier studies suggested that elevated trehalose levels can explain up to 43% of the lifespan extension observed in mutants. Here we demonstrate that trehalose accumulation is responsible for increased osmotolerance, and to some degree thermotolerance, rather than longevity in mutants. This indicates that particular stress resistance phenotypes can be uncoupled from longevity.
胰岛素/胰岛素样生长因子1（IGF-1）信号突变体概括了滞育代谢特征——向脂质和碳水化合物积累的转变——这可能与其长寿和抗应激表型有关。海藻糖是葡萄糖的二糖，在突变体中高度上调，并且它与蛋白质组稳定以及抵御热、冷、干燥和缺氧有关。早期研究表明，海藻糖水平升高可解释在突变体中观察到的高达43%的寿命延长。在这里，我们证明海藻糖积累导致突变体的渗透压耐受性增加，并在一定程度上导致耐热性增加，而不是导致其长寿。这表明特定的抗应激表型可以与长寿脱钩。
