Departamento de Neurodesarrollo y Fisiología, División de Neurociencias, Instituto de Fisiología Celular, UNAM, Ciudad de México 04510, Mexico.
Laboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Ciudad de México 04530, Mexico.
Cells. 2021 Sep 8;10(9):2359. doi: 10.3390/cells10092359.
Health and lifespan are influenced by dietary nutrients, whose balance is dependent on the supply or demand of each organism. Many studies have shown that an increased carbohydrate-lipid intake plays a critical role in metabolic dysregulation, which impacts longevity. has been successfully used as an in vivo model to study the effects of several factors, such as genetic, environmental, diet, and lifestyle factors, on the molecular mechanisms that have been linked to healthspan, lifespan, and the aging process. There is evidence showing the causative effects of high glucose on lifespan in different diabetic models; however, the precise biological mechanisms affected by dietary nutrients, specifically carbohydrates and lipids, as well as their links with lifespan and longevity, remain unknown. Here, we provide an overview of the deleterious effects caused by high-carbohydrate and high-lipid diets, as well as the molecular signals that affect the lifespan of ; thus, understanding the detailed molecular mechanisms of high-glucose- and lipid-induced changes in whole organisms would allow the targeting of key regulatory factors to ameliorate metabolic disorders and age-related diseases.
健康和寿命受到饮食营养的影响，其平衡取决于每个生物体的供应或需求。许多研究表明，增加碳水化合物-脂质的摄入在代谢失调中起着关键作用，从而影响寿命。 已成功用作体内模型，研究了遗传、环境、饮食和生活方式等多种因素对与健康寿命、寿命和衰老过程相关的分子机制的影响。有证据表明，高葡萄糖对不同糖尿病模型中寿命的因果影响；然而，饮食营养（特别是碳水化合物和脂质）以及它们与寿命和长寿的联系所受的具体生物学机制尚不清楚。在这里，我们概述了高碳水化合物和高脂肪饮食引起的有害影响，以及影响寿命的分子信号；因此，了解高糖和脂质诱导的整个生物体变化的详细分子机制将允许针对关键调节因子来改善代谢紊乱和与年龄相关的疾病。
