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使用 scCVD 金刚石膜微剂量计在临床质子束中同时测量剂量和微剂量谱。

Simultaneous Measurements of Dose and Microdosimetric Spectra in a Clinical Proton Beam Using a scCVD Diamond Membrane Microdosimeter.

机构信息

Université Paris-Saclay, CEA, List, F-91120 Palaiseau, France.

Institut Curie, Radiation Oncology Department, PSL Research University, Proton Therapy Centre, Centre Universitaire, 91898 Orsay, France.

出版信息

Sensors (Basel). 2021 Feb 12;21(4):1314. doi: 10.3390/s21041314.

Abstract

A single crystal chemical vapor deposition (scCVD) diamond membrane-based microdosimetric system was used to perform simultaneous measurements of dose profile and microdosimetric spectra with the Y1 proton passive scattering beamline of the Center of Proton Therapy, Institute Curie in Orsay, France. To qualify the performance of the set-up in clinical conditions of hadrontherapy, the dose, dose rate and energy loss pulse-height spectra in a diamond microdosimeter were recorded at multiple points along depth of a water-equivalent plastic phantom. The dose-mean lineal energy (y¯D) values were computed from experimental data and compared to silicon on insulator (SOI) microdosimeter literature results. In addition, the measured dose profile, pulse height spectra and y¯D values were benchmarked with a numerical simulation using TOPAS and Geant4 toolkits. These first clinical tests of a novel system confirm that diamond is a promising candidate for a tissue equivalent, radiation hard, high spatial resolution microdosimeter in beam quality assurance of proton therapy.

摘要

采用单晶化学气相沉积(scCVD)金刚石膜微剂量学系统,在法国奥赛居里质子治疗中心的 Y1 质子被动散射束线上进行剂量分布和微剂量谱的同步测量。为了在重离子治疗的临床条件下验证该装置的性能,在水等效塑料体模的深度方向上的多个点记录了金刚石微剂量计中的剂量、剂量率和能量损失脉冲高度谱。从实验数据计算出剂量平均线性能量 y¯D 值,并与硅衬底上绝缘体(SOI)微剂量计文献结果进行比较。此外,使用 TOPAS 和 Geant4 工具包对测量的剂量分布、脉冲高度谱和 y¯D 值进行了数值模拟验证。该新型系统的首次临床测试证实,金刚石是质子治疗束流质量保证中组织等效、辐射硬度高、空间分辨率高的微剂量计的有前途的候选材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c11/7918314/bdac04f4076b/sensors-21-01314-g001.jpg

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