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新冠疫情危机:植物生物技术如何发挥作用?

COVID-19 Crisis: How Can Plant Biotechnology Help?

作者信息

Shohag Md Jahidul Islam, Khan Farhana Zerin, Tang Lin, Wei Yanyan, He Zhenli, Yang Xiaoe

机构信息

College of Environmental and Resources Science, Zhejiang University, Ministry of Education (MOE) Key Laboratory of Environmental Remediation and Ecosystem Health, Hangzhou 310058, China.

Department of Agriculture, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh.

出版信息

Plants (Basel). 2021 Feb 12;10(2):352. doi: 10.3390/plants10020352.

Abstract

The emergence of the COVID-19 pandemic has led to significant public health crisis all over the world. The rapid spreading nature and high mortality rate of COVID-19 places a huge pressure on scientists to develop effective diagnostics and therapeutics to control the pandemic. Some scientists working on plant biotechnology together with commercial enterprises for the emergency manufacturing of diagnostics and therapeutics have aimed to fulfill the rapid demand for SARS-CoV-2 protein antigen and antibody through a rapid, scalable technology known as transient/stable expression in plants. Plant biotechnology using transient/stable expression offers a rapid solution to address this crisis through the production of low-cost diagnostics, antiviral drugs, immunotherapy, and vaccines. Transient/stable expression technology for manufacturing plant-based biopharmaceuticals is already established at commercial scale. Here, current opinions regarding how plant biotechnology can help fight against COVID-19 through the production of low-cost diagnostics and therapeutics are discussed.

摘要

新冠疫情的出现给全球带来了重大的公共卫生危机。新冠病毒传播迅速且死亡率高,这给科学家们带来了巨大压力,促使他们开发有效的诊断方法和治疗手段来控制疫情。一些从事植物生物技术研究的科学家与商业企业合作,紧急生产诊断试剂和治疗药物,旨在通过一种名为植物瞬时/稳定表达的快速、可扩展技术来满足对新冠病毒蛋白抗原和抗体的快速需求。利用瞬时/稳定表达的植物生物技术通过生产低成本的诊断试剂、抗病毒药物、免疫疗法和疫苗,为应对这一危机提供了快速解决方案。用于生产植物源生物制药的瞬时/稳定表达技术已在商业规模上确立。在此,我们讨论了关于植物生物技术如何通过生产低成本的诊断试剂和治疗药物来帮助抗击新冠疫情的当前观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c22/7917634/1ef5f6c6edf0/plants-10-00352-g001.jpg

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