Department of Orthodontics, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.
EigenChem Technologies Inc., Alachua, FL 32615, USA.
Molecules. 2021 Feb 12;26(4):983. doi: 10.3390/molecules26040983.
Local anesthetics are widely utilized in dentistry, cosmetology, and medicine. Local anesthesia is essential to providing a pain-free experience during dental and local surgeries as well as cosmetic procedures. However, the injection itself may produce discomfort and be a source of aversion. A novel approach toward the taste modulation of local anesthetics is proposed, in which the anesthetics of the "-caine" family serve as cations and are coupled with anionic sweeteners such as saccharinate and acesulfamate. Ionic conjugates of vasoconstrictor epinephrine such as epinephrine saccharinate and epinephrine acesulfamate have also been synthesized. Novel ionic conjugates were developed using anion exchange techniques. Reported compounds are sweet-tasting and are safe to use both topically and as injections.
局部麻醉剂在牙科、美容和医学领域得到广泛应用。局部麻醉对于在牙科和局部手术以及美容程序中提供无痛体验至关重要。然而，注射本身可能会引起不适，并成为人们反感的原因。本文提出了一种局部麻醉剂味觉调制的新方法，其中“-caine”家族的麻醉剂作为阳离子与 saccharinate 和 acesulfamate 等阴离子甜味剂结合。也已经合成了血管收缩剂肾上腺素的离子共轭物，如肾上腺素 saccharinate 和肾上腺素 acesulfamate。新型离子共轭物是使用阴离子交换技术开发的。报道的化合物具有甜味，可以安全地用于局部和注射。
