Chou Hsuan-Wen, Hung Hao-Chang, Lin Ching-Han, Lin An-Chi, Du Ye-Fong, Cheng Kai-Pi, Li Chung-Hao, Chang Chih-Jen, Wu Hung-Tsung, Ou Horng-Yih
Division of Endocrinology and Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan.
Department of Health Management Center, National Cheng Kung University Hospital, National Cheng Kung University, Tainan 70403, Taiwan.
J Clin Med. 2021 Feb 12;10(4):742. doi: 10.3390/jcm10040742.
Although it was known that obesity is an independent risk factor for metabolic disorders including diabetes, the factors that link these diseases were obscure. The Hedgehog-interacting protein (Hhip) is a negative regulator in tissue remodeling, and inhibits the proliferation of adipocytes, and promotes their differentiation. In addition, Hhip was positively associated with diabetes. However, the relationship between Hhip and obesity in the human body remains unclear. An analysis of the relationship between Hhip and normal weight, overweight, and obesity levels. Participants receiving a physical checkup were recruited. Anthropometric and biochemical data were collected. Serum Hhip levels were determined by enzyme-linked immunosorbent assay (ELISA). Subjects were classified into normal-weight, overweight, and obese groups based on their body mass index (BMI). The association between Hhip and obesity was examined by multivariate linear regression analysis. In total, 294 subjects who were either of a normal weight ( = 166), overweight ( = 90), or obese ( = 38) were enrolled. Hhip concentrations were 6.51 ± 4.86 ng/mL, 5.79 ± 4.33 ng/mL, and 3.97 ± 3.4 ng/mL in normal-weight, overweight, and obese groups, respectively ( for trend = 0.032). Moreover, the regression analysis showed that BMI (β = -0.144, 95% confidence interval (CI) = -0.397-0.046, 0.013) was negatively associated with Hhip concentrations after adjusting for sex and age. Being overweight (β = -0.181, 95% CI = -3.311-0.400, 0.013) and obese (β = -0.311, 95% CI = -6.393-2.384, < 0.001) were independently associated with Hhip concentrations after adjusting for sex, age, fasting plasma glucose, the insulin level, and other cardiometabolic risk factors. Our results showed that overweight and obese subjects had lower Hhip concentrations than those of normal weight. Being overweight and obese were negatively associated with Hhip concentrations. Hhip might be a link between obesity and diabetes.
尽管已知肥胖是包括糖尿病在内的代谢紊乱的独立危险因素，但将这些疾病联系起来的因素尚不清楚。刺猬相互作用蛋白（Hhip）是组织重塑中的负调节因子，可抑制脂肪细胞的增殖，并促进其分化。此外，Hhip与糖尿病呈正相关。然而，Hhip与人体肥胖之间的关系仍不清楚。分析Hhip与正常体重、超重和肥胖水平之间的关系。招募接受体检的参与者。收集人体测量和生化数据。通过酶联免疫吸附测定（ELISA）测定血清Hhip水平。根据体重指数（BMI）将受试者分为正常体重、超重和肥胖组。通过多元线性回归分析检验Hhip与肥胖之间的关联。总共纳入了294名正常体重（n = 166）、超重（n = 90）或肥胖（n = 38）的受试者。正常体重、超重和肥胖组的Hhip浓度分别为6.51±4.86 ng/mL、5.79±4.33 ng/mL和3.97±3.4 ng/mL（趋势P = 0.032）。此外，回归分析表明，在调整性别和年龄后，BMI（β = -0.144，95%置信区间（CI）= -0.397 - 0.046，P = 0.013）与Hhip浓度呈负相关。在调整性别、年龄、空腹血糖、胰岛素水平和其他心血管代谢危险因素后，超重（β = -0.181，95% CI = -3.311 - 0.400，P = 0.013）和肥胖（β = -0.311，95% CI = -6.393 - 2.384，P < 0.001）与Hhip浓度独立相关。我们的结果表明，超重和肥胖受试者的Hhip浓度低于正常体重者。超重和肥胖与Hhip浓度呈负相关。Hhip可能是肥胖与糖尿病之间的一个联系。
