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评估富含亚麻籽木脂素的提取物针对自噬、凋亡和刺猬信号通路对实验性诱导肥胖的作用。

Evaluation of flaxseed lignan-enriched extract targeting autophagy, apoptosis, and hedgehog pathways against experimentally induced obesity.

作者信息

Khater Safaa I, Shalabi Maram, Alammash Buthainah B, Alrais Alaa I, Al-Ahmadi Doaa S, Alqahtani Leena S, Khameis Tarek, Abdelaziz Sahar, Elkelish Amr, El-Dawy Kh

机构信息

Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

King Fahad Hospital, Ministry of Health, Medina, Saudi Arabia.

出版信息

J Adv Vet Anim Res. 2023 Jun 30;10(2):321-335. doi: 10.5455/javar.2023.j684. eCollection 2023 Jun.

DOI:10.5455/javar.2023.j684
PMID:37534085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10390674/
Abstract

OBJECTIVE

This research investigated secoisolariciresinol diglucoside (SDG) flax extract effects on apoptosis, hedgehog (Hh), autophagy, and the anti-oxidation process in experimentally induced obesity.

MATERIALS AND METHODS

Forty rats were separated into two sets regarding either receiving a normal balanced diet or a high-fat diet (HFD) and then distributed into four groups: GI: The control group had a regular diet for 12 weeks. GII: animals received a high-fat meal and saline by gastric gavage. GIII: HFD obese rats treated with SDG extract orally (10 mg/kg/b.w.) and 1.18 mg SDG/kg in the diet for 4 weeks GIV: Normal balanced diet rats received SDG extract orally (10 mg/kg/b.w.) and 1.18 mg SDG/kg of chow for 12 weeks in addition to their regular balanced diet.

RESULTS

The administration of SDG extract exhibited a significant drop in body weight, glucose, lipid profile, and leptin compared to the obese group. It also improved the antioxidant levels (lowering the levels of malondialdehyde while increasing the total antioxidant capacity) and anti-inflammatory status (decreasing interleukin-6 and tumor necrosis factor-alpha). SDG extract downregulates the expression of HH genes (protein patched homolog 1, Hh-interacting protein, glioma-associated oncogene homolog 1, and smoothened receptor) in conjunction with the modulation of autophagy genes and apoptotic proteins.

CONCLUSION

SDG extract showed improved anti-inflammatory and antioxidant status and downregulated the expression of HH genes while modulating autophagy genes and apoptotic proteins among obese rats, suggesting that it may be used to avert and manage obesity and its correlated complications by modulating oxidation, inflammation, autophagy, and apoptosis. Advanced future research on the SDG autophagy pathway to address obesity and its complications is mandatory.

摘要

目的

本研究调查了开环异落叶松树脂酚二葡萄糖苷（SDG）亚麻提取物对实验性诱导肥胖中细胞凋亡、刺猬信号通路（Hh）、自噬和抗氧化过程的影响。

材料与方法

40只大鼠根据饮食情况分为两组，即正常平衡饮食组或高脂饮食组（HFD），然后再分为四组：GI：对照组给予常规饮食12周。GII：动物通过胃管给予高脂餐和生理盐水。GIII：高脂饮食诱导的肥胖大鼠口服SDG提取物（10mg/kg体重），饮食中添加1.18mg SDG/kg，持续4周。GIV：正常平衡饮食大鼠除常规平衡饮食外，口服SDG提取物（10mg/kg体重），饮食中添加1.18mg SDG/kg，持续12周。

结果

与肥胖组相比，给予SDG提取物后体重、血糖、血脂和瘦素水平显著下降。它还提高了抗氧化水平（降低丙二醛水平，同时增加总抗氧化能力）和抗炎状态（降低白细胞介素-6和肿瘤坏死因子-α）。SDG提取物下调HH基因（蛋白patched同源物1、Hh相互作用蛋白、神经胶质瘤相关癌基因同源物1和平滑受体）的表达，同时调节自噬基因和凋亡蛋白。

结论

SDG提取物在肥胖大鼠中显示出改善的抗炎和抗氧化状态，下调HH基因的表达，同时调节自噬基因和凋亡蛋白，表明它可能通过调节氧化、炎症、自噬和凋亡来预防和管理肥胖及其相关并发症。未来必须对SDG自噬途径进行进一步研究，以解决肥胖及其并发症问题。

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