Huchim-Chablé María, de Arredondo Roberto Sosa-Martínez, Rivero-Navarrete José Alberto, Mendiburu-Zavala Celia, Cárdenas-Erosa Rubén, Peñaloza-Cuevas Ricardo
General Dentistry Private Practice; Av. Itzaes # 252 X 29 Colonia García Ginerés, Mérida 97070, Yucatán, Mexico.
Private Practice, Central Odontológica of Yucatán; 26 Street # 218-B X 27 and 29, Colonia García Ginerés, Mérida 97070, Yucatán, Mexico.
Materials (Basel). 2021 Feb 27;14(5):1126. doi: 10.3390/ma14051126.
The aim of this study was to evaluate the mixture of Calcium Sulfate and Plasma Rich in Growth Factors (CaSO + PRGF) as a bone-graft substitute in extracted mandibular third molar (MTM) alveoli during a 4-month period. Bilateral MTM extractions were performed in 10 patients (18-25 years) at the Oral-Surgery-Clinic of the Universidad Autónoma de Yucatán (UADY). A CaSO + PRGF mixture was placed in the right alveolus (Experimental Group (EG)) and a natural blood clot in the left (Control Group (CG)). Monthly X-ray controls were performed using a gray scale to measure Bone Regeneration (BR). A non-parametric Sign Test was used to evaluate Radiopacity/Bone Regeneration (Ro/BR) over 4 months, and a Friedman's non-parametric test was used for intra-group analysis over these months. The study was approved by the Centro de Investigaciones Regionales (Dr. Hideyo Noguchi, UADY Bioethics Committee, ID 0026-2015). Using a non-parametric test of the sign, the EG showed significant difference of Ro/BR between groups = 0.002 ( < 0.05). Significant differences were observed in all quadrants and areas = 0.002 ( < 0.05) except in area A in month 4 ( = 0.016), which could be explained by its being the closest to native bone. EG CaSO + PRGF showed a higher degree of bone regeneration compared to CG.
本研究的目的是评估硫酸钙与富含生长因子的血浆（CaSO + PRGF）的混合物作为拔牙后下颌第三磨牙（MTM）牙槽骨移植替代物在4个月期间的效果。在尤卡坦自治大学（UADY）口腔外科诊所，对10名患者（18 - 25岁）进行双侧MTM拔牙。将CaSO + PRGF混合物置于右侧牙槽窝（实验组（EG）），左侧放置天然血凝块（对照组（CG））。每月进行X线对照，使用灰度测量骨再生（BR）。采用非参数符号检验评估4个月内的放射opacity/骨再生（Ro/BR），并使用Friedman非参数检验对这些月份进行组内分析。该研究经区域研究中心（UADY生物伦理委员会野口英世博士，ID 0026 - 2015）批准。使用符号非参数检验，EG组在组间Ro/BR显示出显著差异 = 0.002（<0.05）。除第4个月的A区（ = 0.016）外，所有象限和区域均观察到显著差异 = 0.002（<0.05），这可能是因为它最接近天然骨。与CG组相比，EG组的CaSO + PRGF显示出更高程度的骨再生。
