Amity University Maharashtra, Mumbai - Pune Expressway, Bhatan Post - Somathne, Panvel, Mumbai, Maharashtra 410206, India.
Amity University Maharashtra, Mumbai - Pune Expressway, Bhatan Post - Somathne, Panvel, Mumbai, Maharashtra 410206, India.
Carbohydr Polym. 2021 May 1;259:117696. doi: 10.1016/j.carbpol.2021.117696. Epub 2021 Jan 26.
Doxorubicin (DOX), an anthracycline drug, is widely used for the treatment of several cancers like osteosarcoma, cervical carcinoma, breast cancer, etc. DOX lacks target specificity; thereby it also affects normal cells thus resulting in several side-effects. A drug delivery system (DDS) can be used to deliver the drug in a controlled and sustained manner at a targeted site within the body. Various DDS like nanoemulsions, polymeric nanoparticles, and liposomes are used for loading DOX. Alginate, a polysaccharide is widely used for fabricating DDS due to its biodegradable and bio-compatible properties. Alginates, in combination with other biomaterials, have been extensively used as a novel drug delivery carrier for DOX. Alginate provides a platform for drug delivery in different forms like hydrogels, nanogels, nanoparticles, microparticles, graphene oxide systems, magnetic systems, etc. Herein, we briefly describe alginate in combination with other materials as a nanocarrier for targeted delivery of DOX for anti-cancer treatment.
多柔比星（DOX）是一种蒽环类药物，广泛用于治疗骨肉瘤、宫颈癌、乳腺癌等多种癌症。DOX 缺乏靶向特异性；因此，它也会影响正常细胞，从而导致多种副作用。药物输送系统（DDS）可用于以受控和持续的方式将药物递送至体内靶向部位。各种 DDS，如纳米乳液、聚合物纳米粒子和脂质体，都被用于装载 DOX。藻酸盐是一种多糖，由于其可生物降解和生物相容性，被广泛用于制造 DDS。藻酸盐与其他生物材料结合，已被广泛用作 DOX 的新型药物输送载体。藻酸盐为药物输送提供了不同的形式，如水凝胶、纳米凝胶、纳米粒子、微粒子、氧化石墨烯系统、磁系统等。在这里，我们简要描述了藻酸盐与其他材料结合作为靶向递送 DOX 的纳米载体用于抗癌治疗。
