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基于聚糖的支架和纳米颗粒作为癌症治疗中的药物传递系统。

Glycan-based scaffolds and nanoparticles as drug delivery system in cancer therapy.

机构信息

Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Department of Pharmacy, Peking Union Medical University Hospital, Beijing, China.

出版信息

Front Immunol. 2024 May 10;15:1395187. doi: 10.3389/fimmu.2024.1395187. eCollection 2024.

Abstract

Glycan-based scaffolds are unique in their high specificity, versatility, low immunogenicity, and ability to mimic natural carbohydrates, making them attractive candidates for use in cancer treatment. These scaffolds are made up of glycans, which are biopolymers with well biocompatibility in the human body that can be used for drug delivery. The versatility of glycan-based scaffolds allows for the modulation of drug activity and targeted delivery to specific cells or tissues, which increases the potency of drugs and reduces side effects. Despite their promise, there are still technical challenges in the design and production of glycan-based scaffolds, as well as limitations in their therapeutic efficacy and specificity.

摘要

糖基支架具有高度特异性、多功能性、低免疫原性和模拟天然碳水化合物的能力,因此成为癌症治疗的有吸引力的候选物。这些支架由聚糖组成,聚糖是在人体中具有良好生物相容性的生物聚合物,可用于药物递送。糖基支架的多功能性允许调节药物活性和靶向递送到特定细胞或组织,从而提高药物的效力并降低副作用。尽管有希望,但在糖基支架的设计和生产中仍然存在技术挑战,以及在治疗效果和特异性方面的限制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220c/11116596/58e31e3c0157/fimmu-15-1395187-g001.jpg

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