School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Carbohydr Polym. 2021 May 1;259:117758. doi: 10.1016/j.carbpol.2021.117758. Epub 2021 Feb 6.
This study examined the mechanism of swelling for high acyl (HA) gellan gum and the impacts on the hydrogel mechanical properties and the release of a model drug (glucose). Controlling the material properties and the release of entrapped drugs during use in aqueous environments, such as the stomach or bodily fluids, are crucial in designing functional applications. Swelling of HA gellan gum was controlled by varying the osmotic environment with salts and solvents, and effects on the gel network were characterized by uniaxial compression tests, DSC, and rheology. Low ionic strength solutions caused the greatest degree of swelling (up to 400 %) and corresponded to a more brittle gel with a greater modulus and greater network enthalpy. Swelling slowed the release of glucose by decreasing the diffusion flux. The osmotic environment was found to produce different functional properties, and it is crucial to consider these changes in the design of formulations.
本研究考察了高酰基（HA）结冷胶的溶胀机制及其对水凝胶机械性能和模型药物（葡萄糖）释放的影响。在设计功能性应用时，控制材料特性和在水相环境（如胃或体液）中包埋药物的释放至关重要。通过改变盐和溶剂的渗透环境来控制 HA 结冷胶的溶胀，通过单轴压缩试验、差示扫描量热法和流变学来表征凝胶网络的影响。低离子强度溶液引起的溶胀程度最大（高达 400%），且对应于具有更大模量和更大网络焓的更脆凝胶。溶胀通过降低扩散通量来减缓葡萄糖的释放。发现渗透环境产生了不同的功能特性，在配方设计中必须考虑这些变化。
