早产儿自发性肠穿孔：一项全国性研究。

Spontaneous intestinal perforation in premature infants: a national study.

机构信息

Department of Neonatology, Cleveland Clinic Children's, Cleveland, OH, USA.

Department of Pediatrics, Michigan State University/Sparrow Health System, Lansing, MI, USA.

出版信息

J Perinatol. 2021 May;41(5):1122-1128. doi: 10.1038/s41372-021-00990-2. Epub 2021 Mar 5.

DOI:10.1038/s41372-021-00990-2

PMID:33674711

Abstract

OBJECTIVES

To assess the prevalence and outcomes of spontaneous intestinal perforation (SIP) in very low birth weight infants.

STUDY DESIGN

This cross-sectional study utilized the National Inpatient Sample dataset for the years 2002-2017. All premature infants with birth weight (BW) <1500 g and with gestational age (GA) ≤32 weeks were included. Analyses were repeated after stratifying the population into two BW sub-categories <1000 g and 1000-1499 g. Trend analysis was done using Cochran-Armitage test. Regression analysis was conducted to control for gestational age, race, and sex.

RESULT

A total of 658,001 infants were included. SIP (n = 10,443, 1.6%) was mostly (81.9%) in the category <1000 g with 89.9% ≤28 weeks of gestation. There was a significant trend for increased SIP over the years (p < 0.001). SIP was associated with increased mortality (aOR = 2.24, CI: 2.04-2.46, p < 0.001).

CONCLUSION

After controlling for gestational age and other confounders, SIP is associated with increased mortality in premature infants.

摘要

目的

评估极低出生体重儿自发性肠穿孔（SIP）的发生率和结局。

研究设计

本横断面研究使用了 2002 年至 2017 年的国家住院患者样本数据集。所有出生体重（BW）<1500g 且胎龄（GA）≤32 周的早产儿均纳入研究。在将人群分为两个 BW 亚组<1000g 和 1000-1499g 后，再次进行分析。采用 Cochran-Armitage 检验进行趋势分析。采用回归分析控制胎龄、种族和性别。