Govt. Degree College Kathua, Affiliated to University of Jammu, Jammu, Union Territory of Jammu and Kashmir, 184104, India.
CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi, Union Territory of Jammu and Kashmir, 180001, India.
Chirality. 2021 May;33(5):209-225. doi: 10.1002/chir.23304. Epub 2021 Mar 6.
Over the last few years, there has been a dramatic increase in the number of reports related to Arthrobacter sp. lipase (ABL:MTCC No. 5125) catalyzed kinetic resolution performed in biphasic media. A strain displaying esterase/lipase activity and designated as ABL was isolated, during the course of a screening program at Indian Institute of Integrative Medicine, Jammu. Considerable research has shown that reactions catalyzed by ABL are more selective than many commercial lipases. Since new applications of this lipase are emerging, there is a great need to provide all the relevant information exclusively. This review article is an attempt to cover all the relevant reports based on isolation, purification, immobilization, and application of ABL in the biopharmaceutical sector.
在过去的几年中，有关节杆菌属 sp。脂肪酶（ABL：MTCC No.5125）在双相介质中催化动力学拆分的报道数量急剧增加。在印度整合医学研究所的筛选计划过程中，分离出了一株具有酯酶/脂肪酶活性的菌株，并将其命名为 ABL。大量研究表明，ABL 催化的反应比许多商业脂肪酶更具选择性。由于这种脂肪酶的新应用不断涌现，因此非常需要专门提供所有相关信息。这篇综述文章试图涵盖基于 ABL 的分离、纯化、固定化和在生物制药领域的应用的所有相关报告。
