Kimura I, Matsui T, Kimura M
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Jpn J Pharmacol. 1988 Jan;46(1):93-6. doi: 10.1254/jjp.46.93.
Basal pulse rate (PR) and systolic blood pressure (BP) in the tail artery of diabetic KK-CAy mice were compared with those of alloxan- or streptozotocin (STZ)-induced diabetic ddY mice. Significantly higher PR and BP were obtained by the above three kinds of diabetic states when compared with the pre-diabetic state (KK-CAy) or the non-diabetic state (ddY mice). The PR and BP alteration in diabetic KK-CAy mice were significantly different from the PR one in alloxan-mice and from the BP one in STZ-mice, respectively. Both increases in PR and BP by the diabetic state suggest an anticholinergic state.
将糖尿病KK-CAy小鼠尾动脉的基础脉搏率（PR）和收缩压（BP）与四氧嘧啶或链脲佐菌素（STZ）诱导的糖尿病ddY小鼠进行比较。与糖尿病前期状态（KK-CAy）或非糖尿病状态（ddY小鼠）相比，上述三种糖尿病状态下的PR和BP显著更高。糖尿病KK-CAy小鼠的PR和BP变化分别与四氧嘧啶诱导的糖尿病小鼠的PR变化以及STZ诱导的糖尿病小鼠的BP变化显著不同。糖尿病状态导致的PR和BP升高均提示抗胆碱能状态。
