Department of Ophthalmology, Kangwon National University School of Medicine, Chuncheon, South Korea.
Department of Ophthalmology, College of Medicine, Chuncheon Sacred Heart Hospital, Hallym University, Chuncheon, Korea.
Ophthalmol Glaucoma. 2021 Sep-Oct;4(5):512-521. doi: 10.1016/j.ogla.2021.02.003. Epub 2021 Mar 3.
To compare the characteristics of the peripapillary choroid (PPC) between the 2 eyes of patients with unilateral treatment-naïve normal-tension glaucoma (NTG).
Observational case series.
Sixty-nine patients (138 eyes) with treatment-naïve unilateral NTG.
The characteristics of PPC vasculature were evaluated by measuring PPC thickness and assessing the presence of parapapillary deep-layer microvasculature dropout (MvD). Peripapillary choroid thickness was measured by enhanced depth imaging OCT. Microvasculature dropout was assessed using OCT angiography. The area and maximum radial width of β-zone parapapillary atrophy (PPA) were measured on infrared images using the built-in caliper tool of the Spectralis OCT (Heidelberg Engineering).
Between-eye differences in PPC thickness, MvD frequency, and the area and maximum width of β-zone PPA.
Eyes with NTG showed higher intraocular pressure (IOP), longer axial length, thinner PPC, larger area and maximum radial width of the β-zone PPA, and more frequent MvD (P < 0.01 for each) than contralateral healthy eyes. Multivariate conditional logistic regression analysis revealed that higher IOP, thinner PPC, larger maximum radial width of β-zone PPA, and the presence of MvD were associated independently with the risk of NTG (P < 0.03 for each). In eyes with NTG, MvD location and retinal nerve fiber layer defect were correlated topographically.
Peripapillary choroid vasculature characteristics are significantly more compromised in eyes with NTG than in contralateral healthy eyes of patients with unilateral NTG.
比较单侧未经治疗的正常眼压性青光眼（NTG）患者双眼的视盘周围脉络膜（PPC）特征。
观察性病例系列。
69 例（138 只眼）未经治疗的单侧 NTG 患者。
通过测量 PPC 厚度和评估视盘周围深层微血管丢失（MvD）的存在来评估 PPC 血管特征。使用增强深度成像 OCT 测量视盘周围脉络膜厚度。使用 OCT 血管造影评估微血管丢失。使用 Spectralis OCT（海德堡工程公司）的内置卡尺工具在红外图像上测量β-区视盘周围萎缩（PPA）的面积和最大径向宽度。
PPC 厚度、MvD 频率以及β-区 PPA 的面积和最大宽度的双眼差异。
与对侧健康眼相比，NTG 眼的眼压（IOP）更高、眼轴更长、PPC 更薄、β-区 PPA 的面积和最大径向宽度更大、MvD 更频繁（P<0.01）。多变量条件逻辑回归分析显示，较高的 IOP、较薄的 PPC、较大的β-区 PPA 的最大径向宽度以及 MvD 的存在与 NTG 的风险独立相关（P<0.03）。在 NTG 眼中，MvD 位置与视网膜神经纤维层缺损在地形上相关。
与单侧 NTG 患者对侧健康眼相比，NTG 眼的视盘周围脉络膜血管特征明显受损更严重。
