Department of Ophthalmology, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea.
Hana Seoul Eye Center, Bucheon, Korea.
Korean J Ophthalmol. 2022 Oct;36(5):379-389. doi: 10.3341/kjo.2022.0050. Epub 2022 Aug 19.
To evaluate the correlation between the two methods of measuring the choroidal thickness around the optic nerve head (ONH).
We conducted a cross-sectional study. Sixty-two eyes of 62 healthy subjects were included. Using spectral domain optical coherence tomography, a peripapillary circle scan (diameter of 3.5 mm) and 24 radial B-scan images centered on the Bruch's membrane opening (BMO) were obtained. Peripapillary choroidal thickness (PPCT) and juxtapapillary choroidal thickness (JPCT) were measured using circle and radial B-scan images, respectively. Correlation and agreements between values measured by two methods were analyzed. Factors associated with PPCT and JPCT, and the difference between the values measured by the two methods were evaluated.
A total of 62 eyes of 62 healthy subjects were enrolled. Average PPCT and JPCT were 165.2 ± 50.1 and 139.7 ± 39.2 μm, respectively. The linear regression analysis showed a strong correlation between both measurements (PPCT vs. JPCT, r² = 0.900, p < 0.001). PPCT and JPCT measurements showed good agreement in global and all six sectors (intraclass correlation coefficients >0.900). Bland-Altman plot showed good agreement between the two methods with a systematic deviation of 17.9 μm and a 95% limits of agreement (±1.96 standard deviation) of -9.6 to 60.5. In multivariate regression analysis, BMO area (β = -11.87, p = 0.002) was the only factor significantly correlated with the difference between PPCT and JPCT, which showed a negative correlation. The difference between PPCT and JPCT measurements (PPCT - JPCT) showed a divergent tendency with decreasing BMO area size.
The two measures of choroidal thickness around the ONH were well correlated. However, the peripapillary choroid was generally thicker than the juxtapapillary choroid, especially in eyes with small BMO area.
评估两种测量视神经周围脉络膜厚度（ONH）的方法之间的相关性。
我们进行了一项横断面研究。纳入 62 名 62 只眼的健康受试者。使用频域光学相干断层扫描，获得围绕视盘的 3.5 毫米直径的周边环扫（peripapillary circle scan）和以 Bruch 膜开口（Bruch's membrane opening，BMO）为中心的 24 条径向 B 扫描图像。使用环扫和径向 B 扫描图像分别测量周边脉络膜厚度（peripapillary choroidal thickness，PPCT）和近旁脉络膜厚度（juxtapapillary choroidal thickness，JPCT）。分析两种方法测量值之间的相关性和一致性，并评估与 PPCT 和 JPCT 相关的因素以及两种方法测量值之间的差异。
共纳入 62 名 62 只眼的健康受试者。平均 PPCT 和 JPCT 分别为 165.2 ± 50.1 μm 和 139.7 ± 39.2 μm。线性回归分析显示两种测量值之间存在很强的相关性（PPCT 与 JPCT，r²=0.900，p<0.001）。PPCT 和 JPCT 测量值在全局和所有六个象限（intraclass correlation coefficients>0.900）均具有良好的一致性。Bland-Altman 图显示两种方法之间具有良好的一致性，系统偏差为 17.9 μm，95%一致性界限（±1.96 标准差）为-9.6 至 60.5。多元回归分析显示，BMO 面积（β=-11.87，p=0.002）是唯一与 PPCT 和 JPCT 差值显著相关的因素，两者呈负相关。PPCT 和 JPCT 测量值之间的差异（PPCT-JPCT）随着 BMO 面积的减小呈现出发散趋势。
两种测量视神经周围脉络膜厚度的方法相关性良好。然而，周边脉络膜通常比近旁脉络膜厚，尤其是在 BMO 面积较小的眼中。
